FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146181521> ?p ?o ?g. }

• W2146181521 abstract "Expression and function of the follicle-stimulating hormone receptor (FSHR) in females were long thought to be limited to the ovary. Here, however, we identify extragonadal FSHR in both the human female reproductive tract and the placenta, and test its physiological relevance in mice. We show that in nonpregnant women FSHR is present on: endothelial cells of blood vessels in the endometrium, myometrium, and cervix; endometrial glands of the proliferative and secretory endometrium; cervical glands and the cervical stroma; and (at low levels) stromal cells and muscle fibers of the myometrium. In pregnant women, placental FSHR was detected as early as 8-10 wk of gestation and continued through term. It was expressed on: endothelial cells in fetal portions of the placenta and the umbilical cord; epithelial cells of the amnion; decidualized cells surrounding the maternal arteries in the maternal decidua; and the stromal cells and muscle fibers of the myometrium, with particularly strong expression at term. These findings suggest that FSHR expression is upregulated during decidualization and upregulated in myometrium as a function of pregnancy. The presence of FSHR in the placental vasculature suggests a role in placental angiogenesis. Analysis of genetically modified mice in which Fshr is lacking in fetal portions of the placenta revealed adverse effects on fetoplacental development. Our data further demonstrate FSHB and CGA mRNAs in placenta and uterus, consistent with potential local sources of FSH. Collectively, our data suggest heretofore unappreciated roles of extragonadal FSHR in female reproductive physiology." @default.
• W2146181521 created "2016-06-24" @default.
• W2146181521 creator A5001556393 @default.
• W2146181521 creator A5003343672 @default.
• W2146181521 creator A5004589093 @default.
• W2146181521 creator A5010150395 @default.
• W2146181521 creator A5011911130 @default.
• W2146181521 creator A5035015014 @default.
• W2146181521 creator A5040094428 @default.
• W2146181521 creator A5047017932 @default.
• W2146181521 creator A5080216648 @default.
• W2146181521 date "2014-09-01" @default.
• W2146181521 modified "2023-10-14" @default.
• W2146181521 title "FSH Receptor (FSHR) Expression in Human Extragonadal Reproductive Tissues and the Developing Placenta, and the Impact of Its Deletion on Pregnancy in Mice1" @default.
• W2146181521 cites W1529306536 @default.
• W2146181521 cites W1964681012 @default.
• W2146181521 cites W1965463560 @default.
• W2146181521 cites W1978695171 @default.
• W2146181521 cites W1980514725 @default.
• W2146181521 cites W1984264433 @default.
• W2146181521 cites W1991011758 @default.
• W2146181521 cites W2000828619 @default.
• W2146181521 cites W2018690108 @default.
• W2146181521 cites W2023702153 @default.
• W2146181521 cites W2026726238 @default.
• W2146181521 cites W2027813788 @default.
• W2146181521 cites W2029992524 @default.
• W2146181521 cites W2042538274 @default.
• W2146181521 cites W2044487543 @default.
• W2146181521 cites W2045752787 @default.
• W2146181521 cites W2046148717 @default.
• W2146181521 cites W2052036741 @default.
• W2146181521 cites W2053798532 @default.
• W2146181521 cites W2059922033 @default.
• W2146181521 cites W2064543792 @default.
• W2146181521 cites W2074400318 @default.
• W2146181521 cites W2075616541 @default.
• W2146181521 cites W2076480166 @default.
• W2146181521 cites W2082963600 @default.
• W2146181521 cites W2084990460 @default.
• W2146181521 cites W2085466965 @default.
• W2146181521 cites W2093397599 @default.
• W2146181521 cites W2102298708 @default.
• W2146181521 cites W2103693642 @default.
• W2146181521 cites W2105544539 @default.
• W2146181521 cites W2106205257 @default.
• W2146181521 cites W2109204766 @default.
• W2146181521 cites W2123333548 @default.
• W2146181521 cites W2136191276 @default.
• W2146181521 cites W2140322167 @default.
• W2146181521 cites W2148615135 @default.
• W2146181521 cites W2153533622 @default.
• W2146181521 cites W2157999278 @default.
• W2146181521 cites W2160151670 @default.
• W2146181521 cites W2164002837 @default.
• W2146181521 cites W2164683872 @default.
• W2146181521 cites W2169969051 @default.
• W2146181521 cites W2171740008 @default.
• W2146181521 doi "https://doi.org/10.1095/biolreprod.114.118562" @default.
• W2146181521 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4435062" @default.
• W2146181521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25100706" @default.
• W2146181521 hasPublicationYear "2014" @default.
• W2146181521 type Work @default.
• W2146181521 sameAs 2146181521 @default.
• W2146181521 citedByCount "82" @default.
• W2146181521 countsByYear W21461815212015 @default.
• W2146181521 countsByYear W21461815212016 @default.
• W2146181521 countsByYear W21461815212017 @default.
• W2146181521 countsByYear W21461815212018 @default.
• W2146181521 countsByYear W21461815212019 @default.
• W2146181521 countsByYear W21461815212020 @default.
• W2146181521 countsByYear W21461815212021 @default.
• W2146181521 countsByYear W21461815212022 @default.
• W2146181521 countsByYear W21461815212023 @default.
• W2146181521 crossrefType "journal-article" @default.
• W2146181521 hasAuthorship W2146181521A5001556393 @default.
• W2146181521 hasAuthorship W2146181521A5003343672 @default.
• W2146181521 hasAuthorship W2146181521A5004589093 @default.
• W2146181521 hasAuthorship W2146181521A5010150395 @default.
• W2146181521 hasAuthorship W2146181521A5011911130 @default.
• W2146181521 hasAuthorship W2146181521A5035015014 @default.
• W2146181521 hasAuthorship W2146181521A5040094428 @default.
• W2146181521 hasAuthorship W2146181521A5047017932 @default.
• W2146181521 hasAuthorship W2146181521A5080216648 @default.
• W2146181521 hasBestOaLocation W21461815211 @default.
• W2146181521 hasConcept C126322002 @default.
• W2146181521 hasConcept C134018914 @default.
• W2146181521 hasConcept C16685009 @default.
• W2146181521 hasConcept C16930146 @default.
• W2146181521 hasConcept C172680121 @default.
• W2146181521 hasConcept C2776953305 @default.
• W2146181521 hasConcept C2778164554 @default.
• W2146181521 hasConcept C2778316770 @default.
• W2146181521 hasConcept C2778324911 @default.
• W2146181521 hasConcept C2778575703 @default.
• W2146181521 hasConcept C2779066055 @default.
• W2146181521 hasConcept C2779234561 @default.
• W2146181521 hasConcept C2779279165 @default.
• W2146181521 hasConcept C2779742232 @default.
• W2146181521 hasConcept C2780197806 @default.

• next