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• W2146184025 abstract "Congratulations to Peery et al1Peery A.F. et al.Clin Gastroenterol Hepatol. 2013; 11: 1622-1627Abstract Full Text Full Text PDF PubMed Scopus (88) Google Scholar and to Burgell et al2Burgell R.E. et al.Clin Gastroenterol Hepatol. 2013; 11: 1628-1630Abstract Full Text Full Text PDF PubMed Scopus (7) Google Scholar for calling into question the hypothesis of Painter et al3Painter N.S. et al.BMJ. 1971; 2: 450-455Crossref PubMed Scopus (581) Google Scholar about fiber and its role in diverticulosis. The life expectancy in Uganda in 1950 was estimated to be 48 years4Available at: allafrica.com/stories/201110280183.html. Accessed January 15, 2014.Google Scholar just when diverticula were beginning to appear in Western colons. At that time just 3% of Ugandans were living an urban lifestyle. On the other hand, life expectancy in the United Kingdom in 1951 was about age 66, 18 years older.5Available at: http://www.ons.gov.uk/ons/dcp171776_253938.pdf. Accessed January 15, 2014.Google Scholar I propose that diverticulosis is a disease of civilization. If you live in a rural area and you feel a need to fart, then you do not hold it because there is no one around to be insulted. Similarly, if the call to defecate occurs, you defecate; there is no need to hold it in. When persons respond immediately to these messages, I suggest that there is no buildup of pressures in the colon that then lead to development of diverticula. Constipation and a Low-Fiber Diet Are Not Associated With DiverticulosisClinical Gastroenterology and HepatologyVol. 11Issue 12PreviewAsymptomatic diverticulosis is commonly attributed to constipation caused by a low-fiber diet, although evidence for this mechanism is limited. We examined the associations between constipation and low dietary fiber intake with risk of asymptomatic diverticulosis. Full-Text PDF Pathogenesis of Colonic Diverticulosis: Repainting the PictureClinical Gastroenterology and HepatologyVol. 11Issue 12PreviewFirst described in 1700, diverticulosis is now one of the most common gastrointestinal disorders in the Western world. More than 60% of adults older than age 60 have diverticulosis,1 with 4% to 25% of such individuals developing symptoms or complications (so-called diverticular disease).2 A plausible pathogenic hypothesis originally was proposed by Painter and Burkitt3 in 1971 (referred to here as Painter's hypothesis). Consumption of a low-fiber diet results in small-volume, desiccated colonic contents that require the generation of high colonic pressures to progress toward the anus. Full-Text PDF" @default.
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• W2146184025 date "2014-09-01" @default.
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• W2146184025 title "Diverticulosis Is a Disease of Civilization" @default.
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• W2146184025 doi "https://doi.org/10.1016/j.cgh.2014.01.030" @default.
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