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• W2146185951 endingPage "3323" @default.
• W2146185951 startingPage "3315" @default.
• W2146185951 abstract "The human immunodeficiency virus type 1 nucleocytoplasmic shuttle protein Rev moves repeatedly between the cytoplasm, a perinuclear zone, the nucleoli, and nucleoplasmic speckles. In this study, we demonstrated by both indirect immunofluorescence and Western immunoblot analysis that nuclear exit of Rev transdominant negative mutants was defective compared with that of wild-type Rev. The basic and activation domains of Rev signal import and export, respectively, of Rev across the nuclear membrane. In cotransfection experiments, mutants containing mutations of Rev inhibited the nuclear egress of wild-type Rev, thus revealing a novel transdominant negative phenotype." @default.
• W2146185951 created "2016-06-24" @default.
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• W2146185951 creator A5050577587 @default.
• W2146185951 creator A5055629984 @default.
• W2146185951 creator A5066211577 @default.
• W2146185951 date "1995-06-01" @default.
• W2146185951 modified "2023-10-16" @default.
• W2146185951 title "Nuclear export of the human immunodeficiency virus type 1 nucleocytoplasmic shuttle protein Rev is mediated by its activation domain and is blocked by transdominant negative mutants" @default.
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• W2146185951 doi "https://doi.org/10.1128/jvi.69.6.3315-3323.1995" @default.
• W2146185951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/189043" @default.
• W2146185951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7745679" @default.
• W2146185951 hasPublicationYear "1995" @default.
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