FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146201767> ?p ?o ?g. }

• W2146201767 endingPage "11704" @default.
• W2146201767 startingPage "11699" @default.
• W2146201767 abstract "CLC proteins underlie muscle, kidney, bone, and other organ system function by catalyzing the transport of Cl(-) ions across cell and organellar membranes. Some CLC proteins are ion channels while others are pumps that exchange Cl(-) for H(+). The pathway through which Cl(-) ions cross the membrane has been characterized, but the transport of H(+) and the principle by which their movement is coupled to Cl(-) movement is not well understood. Here we show that H(+) transport depends not only on the presence of a specific glutamate residue but also the presence of Cl(-) ions. H(+) transport, however, can be isolated and analyzed in the absence of Cl(-) by mutating the glutamate to alanine and adding carboxylate-containing molecules to solution, consistent with the notion that H(+) transfer is mediated through the entry of a carboxylate group into the anion pathway. Cl(-) ions and carboxylate interact with each other strongly. These data support a mechanism in which the glutamate carboxylate functions as a surrogate Cl(-) ion, but it can accept a H(+) and transfer it between the external solution and the central Cl(-) binding site, coupled to the movement of 2 Cl(-) ions." @default.
• W2146201767 created "2016-06-24" @default.
• W2146201767 creator A5025045433 @default.
• W2146201767 creator A5037807326 @default.
• W2146201767 creator A5083909365 @default.
• W2146201767 date "2012-07-02" @default.
• W2146201767 modified "2023-10-15" @default.
• W2146201767 title "Molecular mechanism of proton transport in CLC Cl ^- /H ⁺ exchange transporters" @default.
• W2146201767 cites W1480846298 @default.
• W2146201767 cites W1539796472 @default.
• W2146201767 cites W1965620778 @default.
• W2146201767 cites W1968804119 @default.
• W2146201767 cites W1980130504 @default.
• W2146201767 cites W1983398269 @default.
• W2146201767 cites W1987018129 @default.
• W2146201767 cites W1994088425 @default.
• W2146201767 cites W1996299574 @default.
• W2146201767 cites W2005501525 @default.
• W2146201767 cites W2007252518 @default.
• W2146201767 cites W2031806724 @default.
• W2146201767 cites W2039708016 @default.
• W2146201767 cites W2065197175 @default.
• W2146201767 cites W2076233064 @default.
• W2146201767 cites W2087391996 @default.
• W2146201767 cites W2090977690 @default.
• W2146201767 cites W2105095499 @default.
• W2146201767 cites W2105921614 @default.
• W2146201767 cites W2110766511 @default.
• W2146201767 cites W2110798143 @default.
• W2146201767 cites W2122919344 @default.
• W2146201767 cites W2124376775 @default.
• W2146201767 cites W2133585173 @default.
• W2146201767 cites W2136482367 @default.
• W2146201767 cites W2141868802 @default.
• W2146201767 cites W2144688162 @default.
• W2146201767 cites W2146941780 @default.
• W2146201767 cites W2156538060 @default.
• W2146201767 cites W2163341755 @default.
• W2146201767 cites W2164797647 @default.
• W2146201767 cites W2164927499 @default.
• W2146201767 cites W2180229411 @default.
• W2146201767 cites W4238542215 @default.
• W2146201767 doi "https://doi.org/10.1073/pnas.1205764109" @default.
• W2146201767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3406864" @default.
• W2146201767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22753511" @default.
• W2146201767 hasPublicationYear "2012" @default.
• W2146201767 type Work @default.
• W2146201767 sameAs 2146201767 @default.
• W2146201767 citedByCount "66" @default.
• W2146201767 countsByYear W21462017672012 @default.
• W2146201767 countsByYear W21462017672013 @default.
• W2146201767 countsByYear W21462017672014 @default.
• W2146201767 countsByYear W21462017672015 @default.
• W2146201767 countsByYear W21462017672016 @default.
• W2146201767 countsByYear W21462017672017 @default.
• W2146201767 countsByYear W21462017672018 @default.
• W2146201767 countsByYear W21462017672019 @default.
• W2146201767 countsByYear W21462017672020 @default.
• W2146201767 countsByYear W21462017672021 @default.
• W2146201767 countsByYear W21462017672022 @default.
• W2146201767 countsByYear W21462017672023 @default.
• W2146201767 crossrefType "journal-article" @default.
• W2146201767 hasAuthorship W2146201767A5025045433 @default.
• W2146201767 hasAuthorship W2146201767A5037807326 @default.
• W2146201767 hasAuthorship W2146201767A5083909365 @default.
• W2146201767 hasBestOaLocation W21462017671 @default.
• W2146201767 hasConcept C115335371 @default.
• W2146201767 hasConcept C12554922 @default.
• W2146201767 hasConcept C144647389 @default.
• W2146201767 hasConcept C145148216 @default.
• W2146201767 hasConcept C178790620 @default.
• W2146201767 hasConcept C185592680 @default.
• W2146201767 hasConcept C2778074193 @default.
• W2146201767 hasConcept C32909587 @default.
• W2146201767 hasConcept C41625074 @default.
• W2146201767 hasConcept C55493867 @default.
• W2146201767 hasConcept C57947595 @default.
• W2146201767 hasConcept C71240020 @default.
• W2146201767 hasConcept C86803240 @default.
• W2146201767 hasConcept C99975950 @default.
• W2146201767 hasConceptScore W2146201767C115335371 @default.
• W2146201767 hasConceptScore W2146201767C12554922 @default.
• W2146201767 hasConceptScore W2146201767C144647389 @default.
• W2146201767 hasConceptScore W2146201767C145148216 @default.
• W2146201767 hasConceptScore W2146201767C178790620 @default.
• W2146201767 hasConceptScore W2146201767C185592680 @default.
• W2146201767 hasConceptScore W2146201767C2778074193 @default.
• W2146201767 hasConceptScore W2146201767C32909587 @default.
• W2146201767 hasConceptScore W2146201767C41625074 @default.
• W2146201767 hasConceptScore W2146201767C55493867 @default.
• W2146201767 hasConceptScore W2146201767C57947595 @default.
• W2146201767 hasConceptScore W2146201767C71240020 @default.
• W2146201767 hasConceptScore W2146201767C86803240 @default.
• W2146201767 hasConceptScore W2146201767C99975950 @default.
• W2146201767 hasIssue "29" @default.
• W2146201767 hasLocation W21462017671 @default.
• W2146201767 hasLocation W21462017672 @default.
• W2146201767 hasLocation W21462017673 @default.

• next