FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146202549> ?p ?o ?g. }

• W2146202549 endingPage "985" @default.
• W2146202549 startingPage "975" @default.
• W2146202549 abstract "Synthetic κ-opioid receptor (KOR) agonists induce dysphoric and pro-depressive effects and variations in the KOR (OPRK1) and prodynorphin (PDYN) genes have been shown to be associated with alcohol dependence. We genotyped 23 single nucleotide polymorphisms (SNPs) in the PDYN and OPRK1 genes in 816 alcohol-dependent subjects and investigated their association with: (1) negative craving measured by a subscale of the Inventory of Drug Taking Situations; (2) a self-reported history of depression; (3) the intensity of depressive symptoms measured by the Beck Depression Inventory-II. In addition, 13 of the 23 PDYN and OPRK1 SNPs, which were previously genotyped in a set of 1248 controls, were used to evaluate association with alcohol dependence. SNP and haplotype tests of association were performed. Analysis of a haplotype spanning the PDYN gene (rs6045784, rs910080, rs2235751, rs2281285) revealed significant association with alcohol dependence (p = 0.00079) and with negative craving (p = 0.0499). A candidate haplotype containing the PDYN rs2281285-rs1997794 SNPs that was previously associated with alcohol dependence was also associated with negative craving (p = 0.024) and alcohol dependence (p = 0.0008) in this study. A trend for association between depression severity and PDYN variation was detected. No associations of OPRK1 gene variation with alcohol dependence or other studied phenotypes were found. These findings support the hypothesis that sequence variation in the PDYN gene contributes to both alcohol dependence and the induction of negative craving in alcohol-dependent subjects." @default.
• W2146202549 created "2016-06-24" @default.
• W2146202549 creator A5002442157 @default.
• W2146202549 creator A5004264491 @default.
• W2146202549 creator A5020288178 @default.
• W2146202549 creator A5023895343 @default.
• W2146202549 creator A5026326407 @default.
• W2146202549 creator A5029433360 @default.
• W2146202549 creator A5044387148 @default.
• W2146202549 creator A5048529058 @default.
• W2146202549 creator A5050515785 @default.
• W2146202549 creator A5053799877 @default.
• W2146202549 creator A5055990260 @default.
• W2146202549 creator A5058999301 @default.
• W2146202549 creator A5072007100 @default.
• W2146202549 creator A5074859163 @default.
• W2146202549 creator A5076545035 @default.
• W2146202549 creator A5077687835 @default.
• W2146202549 creator A5077904075 @default.
• W2146202549 creator A5078344595 @default.
• W2146202549 creator A5083846688 @default.
• W2146202549 date "2013-06-01" @default.
• W2146202549 modified "2023-10-17" @default.
• W2146202549 title "Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states" @default.
• W2146202549 cites W1547613518 @default.
• W2146202549 cites W1671833268 @default.
• W2146202549 cites W1827518096 @default.
• W2146202549 cites W1898039515 @default.
• W2146202549 cites W1964384291 @default.
• W2146202549 cites W1966448429 @default.
• W2146202549 cites W1974910726 @default.
• W2146202549 cites W1977467968 @default.
• W2146202549 cites W1979803024 @default.
• W2146202549 cites W1980915383 @default.
• W2146202549 cites W1991553216 @default.
• W2146202549 cites W1998487269 @default.
• W2146202549 cites W2003977442 @default.
• W2146202549 cites W2004109806 @default.
• W2146202549 cites W2007376383 @default.
• W2146202549 cites W2010455608 @default.
• W2146202549 cites W2022174561 @default.
• W2146202549 cites W2027652863 @default.
• W2146202549 cites W2029507624 @default.
• W2146202549 cites W2032643119 @default.
• W2146202549 cites W2033440445 @default.
• W2146202549 cites W2043858733 @default.
• W2146202549 cites W2054092950 @default.
• W2146202549 cites W2055482245 @default.
• W2146202549 cites W2061099467 @default.
• W2146202549 cites W2069602784 @default.
• W2146202549 cites W2072134629 @default.
• W2146202549 cites W2079086643 @default.
• W2146202549 cites W2084477259 @default.
• W2146202549 cites W2090430326 @default.
• W2146202549 cites W2091829907 @default.
• W2146202549 cites W2096891361 @default.
• W2146202549 cites W2098126593 @default.
• W2146202549 cites W2113046139 @default.
• W2146202549 cites W2119708674 @default.
• W2146202549 cites W2119920227 @default.
• W2146202549 cites W2122449261 @default.
• W2146202549 cites W2125625812 @default.
• W2146202549 cites W2134515607 @default.
• W2146202549 cites W2134783591 @default.
• W2146202549 cites W2145182954 @default.
• W2146202549 cites W2148208755 @default.
• W2146202549 cites W2150077252 @default.
• W2146202549 cites W2155635136 @default.
• W2146202549 cites W2161920974 @default.
• W2146202549 cites W2162530578 @default.
• W2146202549 cites W2163555916 @default.
• W2146202549 cites W2170190816 @default.
• W2146202549 doi "https://doi.org/10.1017/s1461145712001137" @default.
• W2146202549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3901318" @default.
• W2146202549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23101464" @default.
• W2146202549 hasPublicationYear "2013" @default.
• W2146202549 type Work @default.
• W2146202549 sameAs 2146202549 @default.
• W2146202549 citedByCount "34" @default.
• W2146202549 countsByYear W21462025492013 @default.
• W2146202549 countsByYear W21462025492014 @default.
• W2146202549 countsByYear W21462025492015 @default.
• W2146202549 countsByYear W21462025492016 @default.
• W2146202549 countsByYear W21462025492017 @default.
• W2146202549 countsByYear W21462025492018 @default.
• W2146202549 countsByYear W21462025492019 @default.
• W2146202549 countsByYear W21462025492020 @default.
• W2146202549 countsByYear W21462025492021 @default.
• W2146202549 countsByYear W21462025492022 @default.
• W2146202549 countsByYear W21462025492023 @default.
• W2146202549 crossrefType "journal-article" @default.
• W2146202549 hasAuthorship W2146202549A5002442157 @default.
• W2146202549 hasAuthorship W2146202549A5004264491 @default.
• W2146202549 hasAuthorship W2146202549A5020288178 @default.
• W2146202549 hasAuthorship W2146202549A5023895343 @default.
• W2146202549 hasAuthorship W2146202549A5026326407 @default.
• W2146202549 hasAuthorship W2146202549A5029433360 @default.
• W2146202549 hasAuthorship W2146202549A5044387148 @default.

• next