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- W2146205672 abstract "The ability to efficiently deliver a drug to a tumor site is dependent on a wide range of physiologically imposed design constraints. Nanotechnology provides the possibility of creating delivery vehicles where these design constraints can be decoupled, allowing new approaches for reducing the unwanted side effects of systemic delivery, increasing targeting efficiency and efficacy. Here we review the design strategies of the two FDA-approved antibody–drug conjugates (Brentuximab vedotin and Trastuzumab emtansine) and the four FDA-approved nanoparticle-based drug delivery platforms (Doxil, DaunoXome, Marqibo, and Abraxane) in the context of the challenges associated with systemic targeted delivery of a drug to a solid tumor. The lessons learned from these nanomedicines provide an important insight into the key challenges associated with the development of new platforms for systemic delivery of anti-cancer drugs." @default.
- W2146205672 created "2016-06-24" @default.
- W2146205672 creator A5005491968 @default.
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- W2146205672 creator A5061589390 @default.
- W2146205672 creator A5074740842 @default.
- W2146205672 date "2014-08-01" @default.
- W2146205672 modified "2023-10-11" @default.
- W2146205672 title "State-of-the-art in design rules for drug delivery platforms: Lessons learned from FDA-approved nanomedicines" @default.
- W2146205672 cites W140161251 @default.
- W2146205672 cites W1534849470 @default.
- W2146205672 cites W1651193997 @default.
- W2146205672 cites W166778795 @default.
- W2146205672 cites W1960327677 @default.
- W2146205672 cites W1963565300 @default.
- W2146205672 cites W1965495927 @default.
- W2146205672 cites W1966639238 @default.
- W2146205672 cites W1968583232 @default.
- W2146205672 cites W1972163440 @default.
- W2146205672 cites W1973473600 @default.
- W2146205672 cites W1975341277 @default.
- W2146205672 cites W1976041621 @default.
- W2146205672 cites W1980351020 @default.
- W2146205672 cites W1981831440 @default.
- W2146205672 cites W1985241728 @default.
- W2146205672 cites W1985858988 @default.
- W2146205672 cites W1989230986 @default.
- W2146205672 cites W1989353157 @default.
- W2146205672 cites W1990366531 @default.
- W2146205672 cites W1990983926 @default.
- W2146205672 cites W1992175481 @default.
- W2146205672 cites W1993184235 @default.
- W2146205672 cites W1995239905 @default.
- W2146205672 cites W1996752872 @default.
- W2146205672 cites W2002225831 @default.
- W2146205672 cites W2002256676 @default.
- W2146205672 cites W2004016712 @default.
- W2146205672 cites W2006165138 @default.
- W2146205672 cites W2008008775 @default.
- W2146205672 cites W2008423270 @default.
- W2146205672 cites W2009230632 @default.
- W2146205672 cites W2011118089 @default.
- W2146205672 cites W2013342651 @default.
- W2146205672 cites W2014756142 @default.
- W2146205672 cites W2018989052 @default.
- W2146205672 cites W2022275406 @default.
- W2146205672 cites W2023250799 @default.
- W2146205672 cites W2027437657 @default.
- W2146205672 cites W2029804518 @default.
- W2146205672 cites W2032760352 @default.
- W2146205672 cites W2036944284 @default.
- W2146205672 cites W2039949492 @default.
- W2146205672 cites W2045485835 @default.
- W2146205672 cites W2048011687 @default.
- W2146205672 cites W2053277232 @default.
- W2146205672 cites W2060459188 @default.
- W2146205672 cites W2060537783 @default.
- W2146205672 cites W2061510929 @default.
- W2146205672 cites W2063443915 @default.
- W2146205672 cites W2072997205 @default.
- W2146205672 cites W2073498982 @default.
- W2146205672 cites W2074049796 @default.
- W2146205672 cites W2074544404 @default.
- W2146205672 cites W2075611550 @default.
- W2146205672 cites W2077861960 @default.
- W2146205672 cites W2078628247 @default.
- W2146205672 cites W2080076901 @default.
- W2146205672 cites W2083483697 @default.
- W2146205672 cites W2083982805 @default.
- W2146205672 cites W2089096027 @default.
- W2146205672 cites W2096593771 @default.
- W2146205672 cites W2097203662 @default.
- W2146205672 cites W2100508256 @default.
- W2146205672 cites W2103293124 @default.
- W2146205672 cites W2104354032 @default.
- W2146205672 cites W2104399141 @default.
- W2146205672 cites W2106016270 @default.
- W2146205672 cites W2114500428 @default.
- W2146205672 cites W2117041045 @default.
- W2146205672 cites W2117326659 @default.
- W2146205672 cites W2120766304 @default.
- W2146205672 cites W2123635951 @default.
- W2146205672 cites W2124514746 @default.
- W2146205672 cites W2125123295 @default.
- W2146205672 cites W2128413110 @default.
- W2146205672 cites W2131060408 @default.
- W2146205672 cites W2141540858 @default.
- W2146205672 cites W2147328441 @default.
- W2146205672 cites W2148845753 @default.
- W2146205672 cites W2153771870 @default.
- W2146205672 cites W2154104320 @default.
- W2146205672 cites W2156750162 @default.
- W2146205672 cites W2157963288 @default.
- W2146205672 cites W2159967578 @default.
- W2146205672 cites W2161552291 @default.