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- W2146206588 startingPage "20150036" @default.
- W2146206588 abstract "The evolution of enzymes is often viewed as following a smooth and steady trajectory, from barely functional primordial catalysts to the highly active and specific enzymes that we observe today. In this review, we summarize experimental data that suggest a different reality. Modern examples, such as the emergence of enzymes that hydrolyse human-made pesticides, demonstrate that evolution can be extraordinarily rapid. Experiments to infer and resurrect ancient sequences suggest that some of the first organisms present on the Earth are likely to have possessed highly active enzymes. Reconciling these observations, we argue that rapid bursts of strong selection for increased catalytic efficiency are interspersed with much longer periods in which the catalytic power of an enzyme erodes, through neutral drift and selection for other properties such as cellular energy efficiency or regulation. Thus, many enzymes may have already passed their catalytic peaks." @default.
- W2146206588 created "2016-06-24" @default.
- W2146206588 creator A5025652423 @default.
- W2146206588 creator A5027997186 @default.
- W2146206588 creator A5090221866 @default.
- W2146206588 date "2015-06-01" @default.
- W2146206588 modified "2023-09-24" @default.
- W2146206588 title "Rapid bursts and slow declines: on the possible evolutionary trajectories of enzymes" @default.
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- W2146206588 doi "https://doi.org/10.1098/rsif.2015.0036" @default.
- W2146206588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4590496" @default.
- W2146206588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25926697" @default.
- W2146206588 hasPublicationYear "2015" @default.
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