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- W2146207073 abstract "Haemolytic favism is a severe, acute anaemia which occurs in glucose-6-phosphate dehydrogenase deficient individuals, usually following the ingestion of <i>Vicia faba</i> seeds. Current interest is focused on the nature of the active substances of <i>Vicia faba</i> and on the causes of the varying susceptibility among G6PD-deficient individuals to episodes of severe haemolysis. The results of experiments <i>in vitro</i> favour the hypothesis that <i>Vicia faba</i> contains several active substances which may act in a synergistic way. Red cell acid phosphatase and thalassaemia genes appear to play a remarkable role in conditioning the susceptibility to severe haemolysis in G6PD-deficient subjects. In addition to erythrocyte enzymes and to enzymes which intervene in the absorption and metabolism of the active substances of <i>Vicia faba,</i> another field for future investigations may be that of plasma factors which influence the stability of reduced glutathione in the red cells." @default.
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- W2146207073 title "Favism: Current Problems and Investigations" @default.
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- W2146207073 doi "https://doi.org/10.1136/jmg.10.2.154" @default.
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