Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146221477> ?p ?o ?g. }
- W2146221477 endingPage "2329" @default.
- W2146221477 startingPage "2319" @default.
- W2146221477 abstract "Poly(ADP-ribose) polymerase 2 (PARP-2) is a newly discovered member of the PARP family. We report the association of PARP-2 with mammalian centromeres in a cell-cycle-dependent manner, accumulating at centromeres during prometaphase and metaphase, disassociating during anaphase, and disappearing from the centromeres by telophase. Analysis of a pseudodicentric chromosome and a human neocentromere indicates that PARP-2 binding occurs only at active centromeres in a sequence-independent manner. Centromere binding peaks at the outer centromere region, and is significantly enhanced upon treatment with microtubule-inhibiting drugs. Co-immunoprecipitation assay demonstrates interaction between PARP-2 and its functional homolog PARP-1, constitutive centromere proteins Cenpa and Cenpb, and spindle checkpoint protein Bub3, but not with a third constitutive centromere protein Cenpc. These results, together with our previous demonstration that PARP-1 displays an identical binding pattern with Cenpa, Cenpb and Bub3, but not Cenpc, and that all three proteins undergo significant poly(ADP-ribosyl)ation upon gamma-irradiation of cells, point to possible diverse roles of PARP-2 and PARP-1 in modulating the structure and checkpoint functions of the mammalian centromere, in particular during radiation-induced DNA damage." @default.
- W2146221477 created "2016-06-24" @default.
- W2146221477 creator A5038929472 @default.
- W2146221477 creator A5040434089 @default.
- W2146221477 creator A5065110287 @default.
- W2146221477 creator A5066980521 @default.
- W2146221477 creator A5070769975 @default.
- W2146221477 creator A5082743859 @default.
- W2146221477 date "2002-09-15" @default.
- W2146221477 modified "2023-10-09" @default.
- W2146221477 title "Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc" @default.
- W2146221477 cites W114421267 @default.
- W2146221477 cites W139469382 @default.
- W2146221477 cites W1540858422 @default.
- W2146221477 cites W1546643851 @default.
- W2146221477 cites W1570879094 @default.
- W2146221477 cites W1594629389 @default.
- W2146221477 cites W1606173842 @default.
- W2146221477 cites W1844286590 @default.
- W2146221477 cites W1927775801 @default.
- W2146221477 cites W1934294339 @default.
- W2146221477 cites W1963826216 @default.
- W2146221477 cites W1964699982 @default.
- W2146221477 cites W1973980513 @default.
- W2146221477 cites W1990187458 @default.
- W2146221477 cites W1990579666 @default.
- W2146221477 cites W1992591418 @default.
- W2146221477 cites W1996061199 @default.
- W2146221477 cites W1998147517 @default.
- W2146221477 cites W1999377553 @default.
- W2146221477 cites W2001055161 @default.
- W2146221477 cites W2001431040 @default.
- W2146221477 cites W2004103693 @default.
- W2146221477 cites W2009514478 @default.
- W2146221477 cites W2010167346 @default.
- W2146221477 cites W2014150894 @default.
- W2146221477 cites W2022353228 @default.
- W2146221477 cites W2023431649 @default.
- W2146221477 cites W2030372916 @default.
- W2146221477 cites W2033761616 @default.
- W2146221477 cites W2035475388 @default.
- W2146221477 cites W2037316481 @default.
- W2146221477 cites W2039284286 @default.
- W2146221477 cites W2039426604 @default.
- W2146221477 cites W2042794853 @default.
- W2146221477 cites W2045643757 @default.
- W2146221477 cites W2048735610 @default.
- W2146221477 cites W2058115449 @default.
- W2146221477 cites W2060073273 @default.
- W2146221477 cites W2067153190 @default.
- W2146221477 cites W2067519095 @default.
- W2146221477 cites W2067897696 @default.
- W2146221477 cites W2074955549 @default.
- W2146221477 cites W2077278757 @default.
- W2146221477 cites W2077559325 @default.
- W2146221477 cites W2078358000 @default.
- W2146221477 cites W2078545468 @default.
- W2146221477 cites W2100147739 @default.
- W2146221477 cites W2111644689 @default.
- W2146221477 cites W2111709646 @default.
- W2146221477 cites W2112671059 @default.
- W2146221477 cites W2114460232 @default.
- W2146221477 cites W2117743516 @default.
- W2146221477 cites W2124017626 @default.
- W2146221477 cites W2131865749 @default.
- W2146221477 cites W2136403570 @default.
- W2146221477 cites W2142385508 @default.
- W2146221477 cites W2145921551 @default.
- W2146221477 cites W2148430914 @default.
- W2146221477 cites W2149464818 @default.
- W2146221477 cites W2151797852 @default.
- W2146221477 cites W2153198916 @default.
- W2146221477 cites W2153216034 @default.
- W2146221477 cites W2154241215 @default.
- W2146221477 cites W2155169828 @default.
- W2146221477 cites W2156442575 @default.
- W2146221477 cites W2161522127 @default.
- W2146221477 cites W2163542193 @default.
- W2146221477 cites W2191718011 @default.
- W2146221477 cites W2213813155 @default.
- W2146221477 cites W600510093 @default.
- W2146221477 cites W654533257 @default.
- W2146221477 cites W943460054 @default.
- W2146221477 doi "https://doi.org/10.1093/hmg/11.19.2319" @default.
- W2146221477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12217960" @default.
- W2146221477 hasPublicationYear "2002" @default.
- W2146221477 type Work @default.
- W2146221477 sameAs 2146221477 @default.
- W2146221477 citedByCount "81" @default.
- W2146221477 countsByYear W21462214772012 @default.
- W2146221477 countsByYear W21462214772013 @default.
- W2146221477 countsByYear W21462214772014 @default.
- W2146221477 countsByYear W21462214772015 @default.
- W2146221477 countsByYear W21462214772016 @default.
- W2146221477 countsByYear W21462214772017 @default.
- W2146221477 countsByYear W21462214772018 @default.
- W2146221477 countsByYear W21462214772019 @default.
- W2146221477 countsByYear W21462214772021 @default.