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- W2146222772 endingPage "1028" @default.
- W2146222772 startingPage "1021" @default.
- W2146222772 abstract "A randomized study was conducted in 40 allogeneic marrow recipients to compare the immunogenicity of two Haemophilus influenzae type b (Hib) vaccines (either the Hib capsular polysaccharide [Hib-CPS] or tetanus toxoid-conjugated Hib-CPS [Hib-CPS-T]). A second injection consisted of Hib-CPS-T. Before immunization, 3 patients had serum antibody levels > 1 microgram/mL. After the first injection, the response was better after Hib-CPS-T than after Hib-CPS but lower than in normal subjects; a number of patients lacked any IgG antibody response, especially after Hib-CPS. Of patients who received two injections of Hib-CPS-T, 85% achieved an antibody concentration > or = 1 microgram/mL. Hib-CPS-T induced a response in IgG2-deficient patients whereas Hib-CPS alone did not. IgG antibodies predominantly belonged to the IgG1 subclass. The antibody response was better in patients immunized late after graft. This study shows that Hib-CPS-T is more immunogenic than Hib-CPS in marrow recipients." @default.
- W2146222772 created "2016-06-24" @default.
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- W2146222772 date "1992-11-01" @default.
- W2146222772 modified "2023-10-16" @default.
- W2146222772 title "Immunogenicity of Haemophilus influenzae Type b Conjugate Vaccine in Allogeneic Bone Marrow Recipients" @default.
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- W2146222772 doi "https://doi.org/10.1093/infdis/166.5.1021" @default.
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