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• W2146236477 abstract "<b>Objective and background:</b> To explore the possibility that increased resting heart rate (HR) is associated with a microinflammatory response. Such an association could explain, at least in part, the recently described worse cardiovascular prognosis in individuals with increased HR. <b>Methods:</b> Concentrations of fibrinogen and high-sensitivity C-reactive protein, as well as the absolute number of polymorphonuclear leucocytes, were analysed in a cohort of 4553 apparently healthy men and in those with atherothrombotic risk factors. <b>Results:</b> Following adjustment for age and body mass index, lipid profile and cardiovascular risk factors, a significant (p<0.001) difference was noted between individuals in the first quintile of HR (⩽58 beats/min) and those in the fifth quintile (⩾79 beats/min) regarding all the above-mentioned inflammatory biomarkers, the respective mean values being 7.38 and 8.11 μmol/l, 1.12 and 1.61 mg/l, and 4.23 and 4.74×10⁹/l. <b>Conclusions:</b> Resting HR is associated with a microinflammatory response in apparently healthy men and in those with atherothrombotic risk factors. Sympathetic activation might be a common factor explaining such an association. If confirmed in additional studies, this association might be a relevant target for therapeutic manipulations." @default.
• W2146236477 created "2016-06-24" @default.
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• W2146236477 date "2007-08-01" @default.
• W2146236477 modified "2023-09-26" @default.
• W2146236477 title "Heart rate and microinflammation in men: a relevant atherothrombotic link" @default.
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• W2146236477 doi "https://doi.org/10.1136/hrt.2006.101949" @default.
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