Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146246786> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2146246786 endingPage "12" @default.
- W2146246786 startingPage "1" @default.
- W2146246786 abstract "3D-QSAR of peptides is a daunting task. The difficulty in peptide QSAR arises due to the sheer number of conformational degrees of freedom for peptides that makes alignment in a 3D grid an overwhelming task. In this paper, we propose a method of QSAR where the alignment of peptides is shifted from 3D space to 1D space, making the alignment of peptides a very simple proposition. The method called HomoSAR, is based on an integrated approach that uses the principles of homology modeling in conjunction with the QSAR formalism to predict and design new peptide sequences. The peptides to be studied are subjected to a multiple sequence alignment which is followed by scoring every position in the peptide sequence against a reference peptide in the alignment, through calculation of similarity indices. The similarity indices obtained for each position (amino acid residue) in the peptide form the “descriptor” values (independent variables) which are then correlated to the biological activity of the peptide by G/PLS techniques. As an application, the methodology has been illustrated for the dataset of nonamer peptides that bind to the Class I major histocompatibility complex (MHC) molecule HLA-A∗0201 as this dataset has been extensively studied. The models generated have statistically significant correlation coefficients and predictive r2. The cross validated coefficients (q2) are in an acceptable range. The HomoSAR approach identifies amino acids and properties that are preferred or detrimental at every position in the peptide sequence. The approach is simple to use and is able to extract all information contained in the dataset to explain the underlying structure activity relationships. The approach is applicable to peptide sequences which are not all of uniform length." @default.
- W2146246786 created "2016-06-24" @default.
- W2146246786 creator A5023469457 @default.
- W2146246786 creator A5040450524 @default.
- W2146246786 date "2008-01-01" @default.
- W2146246786 modified "2023-10-16" @default.
- W2146246786 title "HomoSAR: An Integrated Approach Using Homology Modeling and Quantitative Structure-Activity Relationship for Activity Prediction of Peptides" @default.
- W2146246786 cites W1824426708 @default.
- W2146246786 cites W1973269398 @default.
- W2146246786 cites W1989136700 @default.
- W2146246786 cites W1998116826 @default.
- W2146246786 cites W2009387506 @default.
- W2146246786 cites W2012757823 @default.
- W2146246786 cites W2031487111 @default.
- W2146246786 cites W2033153339 @default.
- W2146246786 cites W2034298592 @default.
- W2146246786 cites W2051294170 @default.
- W2146246786 cites W2081142305 @default.
- W2146246786 cites W2085831528 @default.
- W2146246786 cites W2094968966 @default.
- W2146246786 cites W2099254366 @default.
- W2146246786 cites W2105516199 @default.
- W2146246786 cites W2113697512 @default.
- W2146246786 cites W2117057887 @default.
- W2146246786 cites W2122987693 @default.
- W2146246786 cites W2123717481 @default.
- W2146246786 cites W2135455279 @default.
- W2146246786 cites W2140102348 @default.
- W2146246786 cites W2144112248 @default.
- W2146246786 cites W2149840474 @default.
- W2146246786 cites W2161375845 @default.
- W2146246786 cites W2165227116 @default.
- W2146246786 cites W2169281831 @default.
- W2146246786 doi "https://doi.org/10.3814/2008/360572" @default.
- W2146246786 hasPublicationYear "2008" @default.
- W2146246786 type Work @default.
- W2146246786 sameAs 2146246786 @default.
- W2146246786 citedByCount "4" @default.
- W2146246786 countsByYear W21462467862013 @default.
- W2146246786 countsByYear W21462467862015 @default.
- W2146246786 crossrefType "journal-article" @default.
- W2146246786 hasAuthorship W2146246786A5023469457 @default.
- W2146246786 hasAuthorship W2146246786A5040450524 @default.
- W2146246786 hasBestOaLocation W21462467861 @default.
- W2146246786 hasConcept C104317684 @default.
- W2146246786 hasConcept C119857082 @default.
- W2146246786 hasConcept C164126121 @default.
- W2146246786 hasConcept C165525559 @default.
- W2146246786 hasConcept C167625842 @default.
- W2146246786 hasConcept C185592680 @default.
- W2146246786 hasConcept C186060115 @default.
- W2146246786 hasConcept C2779281246 @default.
- W2146246786 hasConcept C33923547 @default.
- W2146246786 hasConcept C41008148 @default.
- W2146246786 hasConcept C515207424 @default.
- W2146246786 hasConcept C55493867 @default.
- W2146246786 hasConcept C70721500 @default.
- W2146246786 hasConcept C86803240 @default.
- W2146246786 hasConceptScore W2146246786C104317684 @default.
- W2146246786 hasConceptScore W2146246786C119857082 @default.
- W2146246786 hasConceptScore W2146246786C164126121 @default.
- W2146246786 hasConceptScore W2146246786C165525559 @default.
- W2146246786 hasConceptScore W2146246786C167625842 @default.
- W2146246786 hasConceptScore W2146246786C185592680 @default.
- W2146246786 hasConceptScore W2146246786C186060115 @default.
- W2146246786 hasConceptScore W2146246786C2779281246 @default.
- W2146246786 hasConceptScore W2146246786C33923547 @default.
- W2146246786 hasConceptScore W2146246786C41008148 @default.
- W2146246786 hasConceptScore W2146246786C515207424 @default.
- W2146246786 hasConceptScore W2146246786C55493867 @default.
- W2146246786 hasConceptScore W2146246786C70721500 @default.
- W2146246786 hasConceptScore W2146246786C86803240 @default.
- W2146246786 hasLocation W21462467861 @default.
- W2146246786 hasOpenAccess W2146246786 @default.
- W2146246786 hasPrimaryLocation W21462467861 @default.
- W2146246786 hasRelatedWork W1495028395 @default.
- W2146246786 hasRelatedWork W1995523102 @default.
- W2146246786 hasRelatedWork W2016062340 @default.
- W2146246786 hasRelatedWork W2020644290 @default.
- W2146246786 hasRelatedWork W2022334616 @default.
- W2146246786 hasRelatedWork W2027683974 @default.
- W2146246786 hasRelatedWork W2037194990 @default.
- W2146246786 hasRelatedWork W2074501933 @default.
- W2146246786 hasRelatedWork W2088205464 @default.
- W2146246786 hasRelatedWork W2189303013 @default.
- W2146246786 hasVolume "2008" @default.
- W2146246786 isParatext "false" @default.
- W2146246786 isRetracted "false" @default.
- W2146246786 magId "2146246786" @default.
- W2146246786 workType "article" @default.