FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146255569> ?p ?o ?g. }

• W2146255569 endingPage "140" @default.
• W2146255569 startingPage "115" @default.
• W2146255569 abstract "Certain partly ordered protein conformations, commonly called “moltenglobule states,” are widely believed to represent protein folding intermediates. Recentstructural studies of molten globule states ofdifferent proteins have revealed features whichappear to be general in scope. The emergingconsensus is that these partly ordered forms exhibit a high content of secondary structure, considerable compactness, nonspecific tertiary structure, and significant structural flexibility. These characteristics may be used to define ageneral state of protein folding called “the molten globule state,” which is structurally andthermodynamically distinct from both the native state and the denatured state. Despite exaatensive knowledge of structural features of afew molten globule states, a cogent thermodynamic argument for their stability has not yetbeen advanced. The prevailing opinion of thelast decade was that there is little or no enthalpy difference or heat capacity differencebetween the molten globule state and the unfolded state. This view, however, appears to beat variance with the existing database of protein structural energetics and with recent estimates of the energetics of denaturation of α-lactalbumin, cytochrome c, apomyoglobin, and T4 lysozyme. We discuss these four proteins at length. The results of structural studies, together with the existing thermodynamic values for fundamental interactions in proteins, provide the foundation for a structural thermodynamic framework which can account for the observed behavior of molten globule states. Within this framework, we analyze the physical basis for both the high stability of several molten globule states and the low probability of other protential folding intermediates. Additionally, we consider, in terms of reduced enthalpy changes and disrupted cooperative interactions, the thermodynamic basis for the apparent absence of a thermally induced, cooperative unfolding transition for some molten globule states. © 1993 Wiley-Liss, Inc." @default.
• W2146255569 created "2016-06-24" @default.
• W2146255569 creator A5007948012 @default.
• W2146255569 creator A5062991013 @default.
• W2146255569 date "1993-06-01" @default.
• W2146255569 modified "2023-09-26" @default.
• W2146255569 title "Structural energetics of the molten globule state" @default.
• W2146255569 cites W113688923 @default.
• W2146255569 cites W114432466 @default.
• W2146255569 cites W1490139598 @default.
• W2146255569 cites W1495475575 @default.
• W2146255569 cites W1496368635 @default.
• W2146255569 cites W1531523283 @default.
• W2146255569 cites W1532491982 @default.
• W2146255569 cites W1544273108 @default.
• W2146255569 cites W1548617948 @default.
• W2146255569 cites W1550390391 @default.
• W2146255569 cites W1563777539 @default.
• W2146255569 cites W1569015250 @default.
• W2146255569 cites W1571251020 @default.
• W2146255569 cites W1581508413 @default.
• W2146255569 cites W1592700388 @default.
• W2146255569 cites W1601832830 @default.
• W2146255569 cites W1602737952 @default.
• W2146255569 cites W1645025205 @default.
• W2146255569 cites W1672294180 @default.
• W2146255569 cites W1691583558 @default.
• W2146255569 cites W1965509947 @default.
• W2146255569 cites W1965849410 @default.
• W2146255569 cites W1967795745 @default.
• W2146255569 cites W1968998311 @default.
• W2146255569 cites W1969939157 @default.
• W2146255569 cites W1971112995 @default.
• W2146255569 cites W1973078025 @default.
• W2146255569 cites W1974347829 @default.
• W2146255569 cites W1975495422 @default.
• W2146255569 cites W1978375665 @default.
• W2146255569 cites W1980045199 @default.
• W2146255569 cites W1981916797 @default.
• W2146255569 cites W1982224344 @default.
• W2146255569 cites W1982803703 @default.
• W2146255569 cites W1983974198 @default.
• W2146255569 cites W1986863965 @default.
• W2146255569 cites W1988397041 @default.
• W2146255569 cites W1988661487 @default.
• W2146255569 cites W1989628468 @default.
• W2146255569 cites W1991302457 @default.
• W2146255569 cites W1996341064 @default.
• W2146255569 cites W1998347411 @default.
• W2146255569 cites W2000116209 @default.
• W2146255569 cites W2001209696 @default.
• W2146255569 cites W2003255208 @default.
• W2146255569 cites W2004421107 @default.
• W2146255569 cites W2004436328 @default.
• W2146255569 cites W2006289998 @default.
• W2146255569 cites W2008035164 @default.
• W2146255569 cites W2012985185 @default.
• W2146255569 cites W2014703877 @default.
• W2146255569 cites W2024379184 @default.
• W2146255569 cites W2029513865 @default.
• W2146255569 cites W2029705130 @default.
• W2146255569 cites W2034125260 @default.
• W2146255569 cites W2035169190 @default.
• W2146255569 cites W2036895460 @default.
• W2146255569 cites W2041450821 @default.
• W2146255569 cites W2042542015 @default.
• W2146255569 cites W2042611798 @default.
• W2146255569 cites W2042995456 @default.
• W2146255569 cites W2044110936 @default.
• W2146255569 cites W2044328480 @default.
• W2146255569 cites W2044791372 @default.
• W2146255569 cites W2051793369 @default.
• W2146255569 cites W2053483740 @default.
• W2146255569 cites W2054342921 @default.
• W2146255569 cites W2055118532 @default.
• W2146255569 cites W2056861114 @default.
• W2146255569 cites W2060960330 @default.
• W2146255569 cites W2062954424 @default.
• W2146255569 cites W2063746089 @default.
• W2146255569 cites W2065210872 @default.
• W2146255569 cites W2067815256 @default.
• W2146255569 cites W2068683917 @default.
• W2146255569 cites W2069148219 @default.
• W2146255569 cites W2072497008 @default.
• W2146255569 cites W2075454119 @default.
• W2146255569 cites W2082025710 @default.
• W2146255569 cites W2082301993 @default.
• W2146255569 cites W2087501877 @default.
• W2146255569 cites W2088525783 @default.
• W2146255569 cites W2107276905 @default.
• W2146255569 cites W2109284125 @default.
• W2146255569 cites W2118295710 @default.
• W2146255569 cites W2119822796 @default.
• W2146255569 cites W2128780962 @default.
• W2146255569 cites W2128954946 @default.
• W2146255569 cites W2134623030 @default.
• W2146255569 cites W2139327615 @default.
• W2146255569 cites W2140040671 @default.

• next