FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146256467> ?p ?o ?g. }

• W2146256467 abstract "The interconnected Ras/ERK and PI3K/AKT pathways play a central role in colorectal tumorigenesis, and they are targets for elucidating mechanisms involved in attempts to induce colon cancer cell death. Both ginger (Zingiber officinale) and honey have been shown to exhibit anti-tumor and anti-inflammation properties against many types of cancer, including colorectal cancer. However, there are currently no reports showing the combined effect of these two dietary compounds in cancer growth inhibition. The aim of this study was to evaluate the synergistic effect of crude ginger extract and Gelam honey in combination as potential cancer chemopreventive agents against the colorectal cancer cell line HT29.The cells were divided into 4 groups: the first group represents HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represents cells treated with ginger and Gelam honey combined.The results of MTS assay showed that the IC50 of ginger and Gelam honey alone were 5.2 mg/ml and 80 mg/ml, respectively, whereas the IC50 of the combination treatment was 3 mg/ml of ginger plus 27 mg/ml of Gelam honey with a combination index of < 1, suggesting synergism. Cell death in response to the combined ginger and Gelam honey treatment was associated with the stimulation of early apoptosis (upregulation of caspase 9 and IκB genes) accompanied by downregulation of the KRAS, ERK, AKT, Bcl-xL, NFkB (p65) genes in a synergistic manner.In conclusion, the combination of ginger and Gelam honey may be an effective chemopreventive and therapeutic strategy for inducing the death of colon cancer cells." @default.
• W2146256467 created "2016-06-24" @default.
• W2146256467 creator A5020817878 @default.
• W2146256467 creator A5034560828 @default.
• W2146256467 creator A5041798800 @default.
• W2146256467 creator A5048264570 @default.
• W2146256467 creator A5055629215 @default.
• W2146256467 creator A5066794633 @default.
• W2146256467 date "2015-04-01" @default.
• W2146256467 modified "2023-10-18" @default.
• W2146256467 title "Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells" @default.
• W2146256467 cites W1505894769 @default.
• W2146256467 cites W1752845679 @default.
• W2146256467 cites W1972997488 @default.
• W2146256467 cites W1974199974 @default.
• W2146256467 cites W1975476791 @default.
• W2146256467 cites W1984119283 @default.
• W2146256467 cites W1991106892 @default.
• W2146256467 cites W1993175949 @default.
• W2146256467 cites W1995847442 @default.
• W2146256467 cites W2001436592 @default.
• W2146256467 cites W2002207325 @default.
• W2146256467 cites W2002801265 @default.
• W2146256467 cites W2004585767 @default.
• W2146256467 cites W2013544554 @default.
• W2146256467 cites W2014164252 @default.
• W2146256467 cites W2020001968 @default.
• W2146256467 cites W2037279051 @default.
• W2146256467 cites W2038309605 @default.
• W2146256467 cites W2061795006 @default.
• W2146256467 cites W2070995184 @default.
• W2146256467 cites W2080719056 @default.
• W2146256467 cites W2084280570 @default.
• W2146256467 cites W2090441772 @default.
• W2146256467 cites W2092874597 @default.
• W2146256467 cites W2099182051 @default.
• W2146256467 cites W2103023937 @default.
• W2146256467 cites W2103562758 @default.
• W2146256467 cites W2104574946 @default.
• W2146256467 cites W2106787323 @default.
• W2146256467 cites W2115899899 @default.
• W2146256467 cites W2120461561 @default.
• W2146256467 cites W2121318534 @default.
• W2146256467 cites W2123884399 @default.
• W2146256467 cites W2132846127 @default.
• W2146256467 cites W2134771624 @default.
• W2146256467 cites W2150683567 @default.
• W2146256467 cites W2151366572 @default.
• W2146256467 cites W2162878542 @default.
• W2146256467 cites W2164157942 @default.
• W2146256467 cites W2166221479 @default.
• W2146256467 cites W2171462836 @default.
• W2146256467 cites W2276313065 @default.
• W2146256467 cites W2789677983 @default.
• W2146256467 cites W4377077044 @default.
• W2146256467 doi "https://doi.org/10.1186/s12937-015-0015-2" @default.
• W2146256467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4390091" @default.
• W2146256467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25889965" @default.
• W2146256467 hasPublicationYear "2015" @default.
• W2146256467 type Work @default.
• W2146256467 sameAs 2146256467 @default.
• W2146256467 citedByCount "86" @default.
• W2146256467 countsByYear W21462564672015 @default.
• W2146256467 countsByYear W21462564672016 @default.
• W2146256467 countsByYear W21462564672017 @default.
• W2146256467 countsByYear W21462564672018 @default.
• W2146256467 countsByYear W21462564672019 @default.
• W2146256467 countsByYear W21462564672020 @default.
• W2146256467 countsByYear W21462564672021 @default.
• W2146256467 countsByYear W21462564672022 @default.
• W2146256467 countsByYear W21462564672023 @default.
• W2146256467 crossrefType "journal-article" @default.
• W2146256467 hasAuthorship W2146256467A5020817878 @default.
• W2146256467 hasAuthorship W2146256467A5034560828 @default.
• W2146256467 hasAuthorship W2146256467A5041798800 @default.
• W2146256467 hasAuthorship W2146256467A5048264570 @default.
• W2146256467 hasAuthorship W2146256467A5055629215 @default.
• W2146256467 hasAuthorship W2146256467A5066794633 @default.
• W2146256467 hasBestOaLocation W21462564671 @default.
• W2146256467 hasConcept C104317684 @default.
• W2146256467 hasConcept C121608353 @default.
• W2146256467 hasConcept C126322002 @default.
• W2146256467 hasConcept C127561419 @default.
• W2146256467 hasConcept C190283241 @default.
• W2146256467 hasConcept C2781187634 @default.
• W2146256467 hasConcept C502942594 @default.
• W2146256467 hasConcept C526805850 @default.
• W2146256467 hasConcept C55493867 @default.
• W2146256467 hasConcept C555283112 @default.
• W2146256467 hasConcept C57074206 @default.
• W2146256467 hasConcept C62478195 @default.
• W2146256467 hasConcept C71924100 @default.
• W2146256467 hasConcept C75217442 @default.
• W2146256467 hasConcept C86554907 @default.
• W2146256467 hasConcept C86803240 @default.
• W2146256467 hasConcept C98274493 @default.
• W2146256467 hasConceptScore W2146256467C104317684 @default.
• W2146256467 hasConceptScore W2146256467C121608353 @default.
• W2146256467 hasConceptScore W2146256467C126322002 @default.
• W2146256467 hasConceptScore W2146256467C127561419 @default.

• next