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- W2146261704 abstract "Streptococcus mutans is a major pathogen implicated in dental caries. Its virulence is enhanced by its ability to produce bacteriocins, called mutacins, which inhibit the growth of other Gram-positive bacteria. The goal of this study is to use a random insertional mutagenesis approach to search for genes that are associated with mutacin I production in the virulent strain UA140. A random insertional mutagenesis library consisting of 11 000 clones was constructed and screened for a mutacin-defective phenotype. Mutacin-defective clones were isolated, and their insertion sites were determined by PCR amplification or plasmid rescue followed by sequencing. A total of twenty-five unique genes were identified. These genes can be categorized into the following functional classes: two-component sensory systems, stress responses, energy metabolism and central cellular processes. Several conserved hypothetical proteins with unknown functions were also identified. These results suggest that mutacin I production is stringently controlled by diverse and complex regulatory pathways." @default.
- W2146261704 created "2016-06-24" @default.
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- W2146261704 creator A5031924369 @default.
- W2146261704 creator A5057339014 @default.
- W2146261704 creator A5062964552 @default.
- W2146261704 date "2005-12-01" @default.
- W2146261704 modified "2023-09-30" @default.
- W2146261704 title "Identification of genes associated with mutacin I production in Streptococcus mutans using random insertional mutagenesis" @default.
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- W2146261704 doi "https://doi.org/10.1099/mic.0.28221-0" @default.
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