FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146262648> ?p ?o ?g. }

• W2146262648 endingPage "50" @default.
• W2146262648 startingPage "40" @default.
• W2146262648 abstract "Olanzapine (OLZ) is an atypical antipsychotic drug that also has mood-stabilizing effects. The mechanism of action of OLZ is not fully understood. Accumulating data suggest that inflammation plays a role in the pathophysiology of mental disorders and that psychotropic drugs exhibit some anti-inflammatory properties. This study was undertaken to examine the effects of OLZ on LPS-induced inflammation in rat primary glia cells. Glia cells were extracted from newborn rat brains. OLZ (1 or 50 µM) was added to culture medium at 6 or 72 h before addition of LPS for another 18 h, and levels of IL-10, prostaglandin (PG) E 2 , NO and TNF-α, and expression of cyclo-oxygensase (COX)-2 and inducible NO synthase (iNOS) were determined. Treatment with 50 µM OLZ (but not 1 µM) significantly decreased LPS-induced secretion of IL-10, PGE 2 and TNF-α. In contrast, 50 µM OLZ significantly increased NO levels. OLZ did not alter the expression of COX-2 or iNOS in LPS-treated cells. These results suggest that OLZ differently affects the secretion of inflammatory mediators. Most of the significant effects of OLZ were obtained when 50 µM was used, which is a high and probably therapeutically irrelevant concentration. Therefore, under the conditions used in the present study OLZ seemed to lack a potent anti-inflammatory effect." @default.
• W2146262648 created "2016-06-24" @default.
• W2146262648 creator A5003992007 @default.
• W2146262648 creator A5010393245 @default.
• W2146262648 date "2015-11-05" @default.
• W2146262648 modified "2023-09-26" @default.
• W2146262648 title "Effects of olanzapine on LPS-induced inflammation in rat primary glia cells" @default.
• W2146262648 cites W1496231157 @default.
• W2146262648 cites W1594425991 @default.
• W2146262648 cites W1880131416 @default.
• W2146262648 cites W1938316342 @default.
• W2146262648 cites W1964368905 @default.
• W2146262648 cites W1968901518 @default.
• W2146262648 cites W1969199763 @default.
• W2146262648 cites W1970022478 @default.
• W2146262648 cites W1972519055 @default.
• W2146262648 cites W1978836458 @default.
• W2146262648 cites W1980463403 @default.
• W2146262648 cites W1982418790 @default.
• W2146262648 cites W1987075369 @default.
• W2146262648 cites W1987216167 @default.
• W2146262648 cites W1988201936 @default.
• W2146262648 cites W1988430501 @default.
• W2146262648 cites W1990802251 @default.
• W2146262648 cites W1992868687 @default.
• W2146262648 cites W1996454121 @default.
• W2146262648 cites W1996879756 @default.
• W2146262648 cites W2002792886 @default.
• W2146262648 cites W2007421151 @default.
• W2146262648 cites W2014858274 @default.
• W2146262648 cites W2015544660 @default.
• W2146262648 cites W2022669082 @default.
• W2146262648 cites W2030396834 @default.
• W2146262648 cites W2032919221 @default.
• W2146262648 cites W2035859458 @default.
• W2146262648 cites W2035981398 @default.
• W2146262648 cites W2038438278 @default.
• W2146262648 cites W2039674246 @default.
• W2146262648 cites W2041806676 @default.
• W2146262648 cites W2043290296 @default.
• W2146262648 cites W2047797335 @default.
• W2146262648 cites W2048866565 @default.
• W2146262648 cites W2049808835 @default.
• W2146262648 cites W2052326590 @default.
• W2146262648 cites W2055915417 @default.
• W2146262648 cites W2059231279 @default.
• W2146262648 cites W2061001694 @default.
• W2146262648 cites W2063044697 @default.
• W2146262648 cites W2064023438 @default.
• W2146262648 cites W2068428998 @default.
• W2146262648 cites W2068997428 @default.
• W2146262648 cites W2071716296 @default.
• W2146262648 cites W2074125037 @default.
• W2146262648 cites W2079254246 @default.
• W2146262648 cites W2081921819 @default.
• W2146262648 cites W2082184929 @default.
• W2146262648 cites W2082279387 @default.
• W2146262648 cites W2082535880 @default.
• W2146262648 cites W2083286809 @default.
• W2146262648 cites W2087456372 @default.
• W2146262648 cites W2088914845 @default.
• W2146262648 cites W2091262599 @default.
• W2146262648 cites W2091401872 @default.
• W2146262648 cites W2091469541 @default.
• W2146262648 cites W2096047662 @default.
• W2146262648 cites W2097594692 @default.
• W2146262648 cites W2102204071 @default.
• W2146262648 cites W2103997793 @default.
• W2146262648 cites W2107178895 @default.
• W2146262648 cites W2109442247 @default.
• W2146262648 cites W2109759840 @default.
• W2146262648 cites W2110194936 @default.
• W2146262648 cites W2123130757 @default.
• W2146262648 cites W2124835767 @default.
• W2146262648 cites W2126853519 @default.
• W2146262648 cites W2131607023 @default.
• W2146262648 cites W2141180259 @default.
• W2146262648 cites W2154746915 @default.
• W2146262648 cites W2157107327 @default.
• W2146262648 cites W2159109510 @default.
• W2146262648 cites W2159155203 @default.
• W2146262648 cites W2159973565 @default.
• W2146262648 cites W2161177698 @default.
• W2146262648 cites W2165451664 @default.
• W2146262648 cites W2166043067 @default.
• W2146262648 cites W2169079754 @default.
• W2146262648 cites W2170561948 @default.
• W2146262648 cites W2171149822 @default.
• W2146262648 cites W2319806219 @default.
• W2146262648 cites W2333485767 @default.
• W2146262648 cites W2948665150 @default.
• W2146262648 cites W4251169171 @default.
• W2146262648 cites W4253487572 @default.
• W2146262648 cites W4293247451 @default.
• W2146262648 cites W79943469 @default.
• W2146262648 doi "https://doi.org/10.1177/1753425915613425" @default.
• W2146262648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26542836" @default.
• W2146262648 hasPublicationYear "2015" @default.

• next