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- W2146268081 abstract "Whisking is controlled by multiple, possibly functionally segregated, motor sensory-motor loops. While testing for effects of endocannabinoids on whisking, we uncovered the first known functional segregation of channels controlling whisking amplitude and timing. Channels controlling amplitude, but not timing, were modulated by cannabinoid receptor type 1 (CB1R). Systemic administration of CB1R agonist Δ(9)-tetrahydrocannabinol (Δ(9)-THC) reduced whisking spectral power across all tested doses (1.25-5 mg/kg), whereas whisking frequency was affected at only very high doses (5 mg/kg). Concomitantly, whisking amplitude and velocity were significantly reduced in a dose-dependent manner (25-43 and 26-50%, respectively), whereas cycle duration and bilateral synchrony were hardly affected (3-16 and 3-9%, respectively). Preadministration of CB1R antagonist SR141716A blocked Δ(9)-THC-induced kinematic alterations of whisking, and when administered alone, increased whisking amplitude and velocity but affected neither cycle duration nor synchrony. These findings indicate that whisking amplitude and timing are controlled by separate channels and that endocannabinoids modulate amplitude control channels." @default.
- W2146268081 created "2016-06-24" @default.
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- W2146268081 creator A5051187229 @default.
- W2146268081 creator A5086879348 @default.
- W2146268081 creator A5088098711 @default.
- W2146268081 date "2010-11-01" @default.
- W2146268081 modified "2023-10-18" @default.
- W2146268081 title "Cannabinoids Reveal Separate Controls for Whisking Amplitude and Timing in Rats" @default.
- W2146268081 cites W1518090354 @default.
- W2146268081 cites W1537201002 @default.
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- W2146268081 cites W190242777 @default.
- W2146268081 cites W1971534047 @default.
- W2146268081 cites W1976137052 @default.
- W2146268081 cites W1977821695 @default.
- W2146268081 cites W1979707551 @default.
- W2146268081 cites W1980195802 @default.
- W2146268081 cites W1980592898 @default.
- W2146268081 cites W1981129339 @default.
- W2146268081 cites W1989756472 @default.
- W2146268081 cites W1991126679 @default.
- W2146268081 cites W1997485399 @default.
- W2146268081 cites W1998532089 @default.
- W2146268081 cites W2000082084 @default.
- W2146268081 cites W2001225304 @default.
- W2146268081 cites W2001972689 @default.
- W2146268081 cites W2005312899 @default.
- W2146268081 cites W2006295913 @default.
- W2146268081 cites W2007023571 @default.
- W2146268081 cites W2008504215 @default.
- W2146268081 cites W2010649745 @default.
- W2146268081 cites W2011109945 @default.
- W2146268081 cites W2015488201 @default.
- W2146268081 cites W2016622169 @default.
- W2146268081 cites W2016943244 @default.
- W2146268081 cites W2017782835 @default.
- W2146268081 cites W2018796939 @default.
- W2146268081 cites W2024686567 @default.
- W2146268081 cites W2029181309 @default.
- W2146268081 cites W2029513180 @default.
- W2146268081 cites W2032116213 @default.
- W2146268081 cites W2038288674 @default.
- W2146268081 cites W2040713547 @default.
- W2146268081 cites W2041422974 @default.
- W2146268081 cites W2043129141 @default.
- W2146268081 cites W2046028526 @default.
- W2146268081 cites W2053547290 @default.
- W2146268081 cites W2055223069 @default.
- W2146268081 cites W2059504616 @default.
- W2146268081 cites W2061488342 @default.
- W2146268081 cites W2062152100 @default.
- W2146268081 cites W2064128689 @default.
- W2146268081 cites W2065150089 @default.
- W2146268081 cites W2065522032 @default.
- W2146268081 cites W2066465804 @default.
- W2146268081 cites W2066634921 @default.
- W2146268081 cites W2070356484 @default.
- W2146268081 cites W2073514289 @default.
- W2146268081 cites W2075894678 @default.
- W2146268081 cites W2081604742 @default.
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- W2146268081 cites W2084821051 @default.
- W2146268081 cites W2087036930 @default.
- W2146268081 cites W2090542239 @default.
- W2146268081 cites W2095689449 @default.
- W2146268081 cites W2099638088 @default.
- W2146268081 cites W2099878623 @default.
- W2146268081 cites W2101290001 @default.
- W2146268081 cites W2106755999 @default.
- W2146268081 cites W2109014188 @default.
- W2146268081 cites W2113576281 @default.
- W2146268081 cites W2114039375 @default.
- W2146268081 cites W2114192904 @default.
- W2146268081 cites W2116573434 @default.
- W2146268081 cites W2124969467 @default.
- W2146268081 cites W2135475275 @default.
- W2146268081 cites W2139794765 @default.
- W2146268081 cites W2141004549 @default.
- W2146268081 cites W2150627463 @default.
- W2146268081 cites W2153498344 @default.
- W2146268081 cites W2163814475 @default.
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- W2146268081 cites W2171275714 @default.
- W2146268081 cites W4231721201 @default.
- W2146268081 cites W90597304 @default.
- W2146268081 doi "https://doi.org/10.1152/jn.01039.2009" @default.
- W2146268081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20844105" @default.
- W2146268081 hasPublicationYear "2010" @default.
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