FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146282659> ?p ?o ?g. }

• W2146282659 endingPage "31" @default.
• W2146282659 startingPage "3425" @default.
• W2146282659 abstract "High-dose chemotherapy (HDCT) is currently under evaluation for high-risk primary breast cancer (HRPBC), defined by extensive axillary nodal involvement or inflammatory breast carcinoma. Phase II studies of HDCT for HRPBC show that 30-40% of patients eventually relapse. We retrospectively reviewed 176 patients enrolled in clinical trials of HDCT for HRPBC at the University of Colorado and analyzed 23 potential predictive variables for relapse. All of the patients received the same regimen, with cyclophosphamide, cisplatin, and BCNU. Nine patients who experienced a toxic death were excluded from this analysis. The resulting predictive model was subsequently tested in an independent patient set treated at Duke University with the same HDCT regimen. Nodal ratio (number of involved nodes:number of sampled nodes), tumor size, grade, stage, estrogen receptor, progesterone receptor, and clinical inflammatory breast carcinoma correlated with risk of relapse. Nodal ratio, tumor size, and the combined estrogen receptor/progesterone receptor status were independent predictors. A scoring system using those three variables determines the risk of relapse, with a sensitivity and specificity of 60 and 90%, respectively, and a positive and negative predictive value of 65 and 88%, respectively. The differences in relapse-free survival and overall survival between high- and low-score patients were highly significant (P<0.000001). This model was subsequently validated in the Duke patient set. This model can identify two subgroups of HRPBC patients with low (12%) and high (65%) risk for recurrence after HDCT. Future research that tests new therapies will focus on those patients with a high score." @default.
• W2146282659 created "2016-06-24" @default.
• W2146282659 creator A5014505996 @default.
• W2146282659 creator A5029237145 @default.
• W2146282659 creator A5032278805 @default.
• W2146282659 creator A5034651124 @default.
• W2146282659 creator A5051544642 @default.
• W2146282659 creator A5055885795 @default.
• W2146282659 creator A5068599434 @default.
• W2146282659 creator A5071526808 @default.
• W2146282659 creator A5088237848 @default.
• W2146282659 date "1999-11-01" @default.
• W2146282659 modified "2023-10-12" @default.
• W2146282659 title "A predictive model for relapse in high-risk primary breast cancer patients treated with high-dose chemotherapy and autologous stem-cell transplant." @default.
• W2146282659 cites W139042253 @default.
• W2146282659 cites W142554672 @default.
• W2146282659 cites W1580788756 @default.
• W2146282659 cites W1748734394 @default.
• W2146282659 cites W1823011883 @default.
• W2146282659 cites W1889359826 @default.
• W2146282659 cites W1929549982 @default.
• W2146282659 cites W1935743463 @default.
• W2146282659 cites W1955397179 @default.
• W2146282659 cites W1979300931 @default.
• W2146282659 cites W1982583218 @default.
• W2146282659 cites W2001445183 @default.
• W2146282659 cites W2010871781 @default.
• W2146282659 cites W2025022077 @default.
• W2146282659 cites W2026686462 @default.
• W2146282659 cites W2050818040 @default.
• W2146282659 cites W20512936 @default.
• W2146282659 cites W2055687655 @default.
• W2146282659 cites W2061032816 @default.
• W2146282659 cites W206480088 @default.
• W2146282659 cites W2083616014 @default.
• W2146282659 cites W2090424555 @default.
• W2146282659 cites W2120093724 @default.
• W2146282659 cites W2151207850 @default.
• W2146282659 cites W2172166169 @default.
• W2146282659 cites W2187668060 @default.
• W2146282659 cites W2231059890 @default.
• W2146282659 cites W2246103289 @default.
• W2146282659 cites W2259609472 @default.
• W2146282659 cites W2264055183 @default.
• W2146282659 cites W2407699923 @default.
• W2146282659 cites W2411591675 @default.
• W2146282659 cites W2414823819 @default.
• W2146282659 cites W2461299720 @default.
• W2146282659 cites W2029496089 @default.
• W2146282659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10589754" @default.
• W2146282659 hasPublicationYear "1999" @default.
• W2146282659 type Work @default.
• W2146282659 sameAs 2146282659 @default.
• W2146282659 citedByCount "13" @default.
• W2146282659 countsByYear W21462826592012 @default.
• W2146282659 crossrefType "journal-article" @default.
• W2146282659 hasAuthorship W2146282659A5014505996 @default.
• W2146282659 hasAuthorship W2146282659A5029237145 @default.
• W2146282659 hasAuthorship W2146282659A5032278805 @default.
• W2146282659 hasAuthorship W2146282659A5034651124 @default.
• W2146282659 hasAuthorship W2146282659A5051544642 @default.
• W2146282659 hasAuthorship W2146282659A5055885795 @default.
• W2146282659 hasAuthorship W2146282659A5068599434 @default.
• W2146282659 hasAuthorship W2146282659A5071526808 @default.
• W2146282659 hasAuthorship W2146282659A5088237848 @default.
• W2146282659 hasConcept C121608353 @default.
• W2146282659 hasConcept C126322002 @default.
• W2146282659 hasConcept C143998085 @default.
• W2146282659 hasConcept C2776694085 @default.
• W2146282659 hasConcept C2776755627 @default.
• W2146282659 hasConcept C2778336483 @default.
• W2146282659 hasConcept C2781413609 @default.
• W2146282659 hasConcept C530470458 @default.
• W2146282659 hasConcept C71924100 @default.
• W2146282659 hasConcept C84606932 @default.
• W2146282659 hasConceptScore W2146282659C121608353 @default.
• W2146282659 hasConceptScore W2146282659C126322002 @default.
• W2146282659 hasConceptScore W2146282659C143998085 @default.
• W2146282659 hasConceptScore W2146282659C2776694085 @default.
• W2146282659 hasConceptScore W2146282659C2776755627 @default.
• W2146282659 hasConceptScore W2146282659C2778336483 @default.
• W2146282659 hasConceptScore W2146282659C2781413609 @default.
• W2146282659 hasConceptScore W2146282659C530470458 @default.
• W2146282659 hasConceptScore W2146282659C71924100 @default.
• W2146282659 hasConceptScore W2146282659C84606932 @default.
• W2146282659 hasIssue "11" @default.
• W2146282659 hasLocation W21462826591 @default.
• W2146282659 hasOpenAccess W2146282659 @default.
• W2146282659 hasPrimaryLocation W21462826591 @default.
• W2146282659 hasRelatedWork W1989798994 @default.
• W2146282659 hasRelatedWork W2002814533 @default.
• W2146282659 hasRelatedWork W2043990561 @default.
• W2146282659 hasRelatedWork W2052163941 @default.
• W2146282659 hasRelatedWork W2369039771 @default.
• W2146282659 hasRelatedWork W2388730008 @default.
• W2146282659 hasRelatedWork W2411519961 @default.
• W2146282659 hasRelatedWork W2768765274 @default.
• W2146282659 hasRelatedWork W3031299550 @default.

• next