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- W2146291845 abstract "Endothelin-1 (ET-1) exerts its biological actions through two receptor subtypes: ETA and ETB. We demonstrated previously that ET-1 induces systemic and renal cortical vasoconstriction via ETA, whereas ETB mediates medullary vasodilation. Congestive heart failure (CHF) is characterized by increased vascular resistance and impaired renal hemodynamic and excretory function. While the pathophysiological effects of ET-1 in CHF are well established, the status of ETA and ETB receptors in the kidney is poorly characterized. We studied the immunostaining and localization of ETA and ETB in the renal cortex and medulla of rats with experimental CHF induced by aorto-caval fistula. Rats with CHF were further subdivided, based on their daily urinary sodium excretion (UNaV), into rats with compensated (UNaV>1200 μEq/day) and decompensated CHF (UNaV<200 μEq/day). ETA is predominantly localized to the cortex, mainly in the peritubular capillaries, and is upregulated in both rats with compensated and decompensated CHF compared with sham operated controls. In contrast, ETB is preferentially expressed in the outer and inner medulla, mainly in vasa recta, thick ascending limb of Henle's loop and collecting duct (CD). While compensated CHF is associated with upregulation of ETB in the CD and vasa recta, decompensated CHF is accompanied with enhanced ETB abundance in the vasa recta and remarkable downregulation of this receptor subtype in the CD. The findings suggest that upregulation of ETA may lead to a decrease in cortical blood flow while upregulation of ETB in the vasa recta probably contributed to the preservation of medullary blood flow. Furthermore, downregulation of ETB in the CD, noted only in rats with decompensated CHF, could contribute to sodium retention in that subgroup. Am J Hypertens (2004) 17, 67A–67A; doi: 10.1016/j.amjhyper.2004.03.168" @default.
- W2146291845 created "2016-06-24" @default.
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- W2146291845 date "2004-05-01" @default.
- W2146291845 modified "2023-09-26" @default.
- W2146291845 title "Differential regulation of renal endothelin eta and etb receptors in rats withexperimental heart failure" @default.
- W2146291845 doi "https://doi.org/10.1016/j.amjhyper.2004.03.168" @default.
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