Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146291969> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2146291969 endingPage "324" @default.
- W2146291969 startingPage "318" @default.
- W2146291969 abstract "1-Furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) has recently been synthesized and characterized to have an anti-inflammatory activity through the inhibition of the production of nitric oxide. In the present study, adverse effects of FPP-3 on hepatic functions were determined in female BALB/c mice. When mice were administered with FPP-3 at 125, 250 or 500 mg/kg for 7 consecutive days orally, FPP-3 significantly increased absolute and relative weights of liver with a dose-dependent manner. In addition, FPP-3 administration dramatically increased the hepatotoxicity parameters in serum at 500 mg/kg, in association of hepatic necrosis. FPP-3 significantly induced several phase I enzyme activities. To elucidate the possible mechanism(s) involved in FPP-3 induced hepatotoxicity, we investigated the hepatic activities of free radical generating and scavenging enzymes and the level of hepatic lipid peroxidation. FPP-3 treatment significantly elevated the hepatic lipid peroxidation, measured as the thiobarbituric acid-reactive substance, and the activity of superoxide dismutase. Taken together, the present data indicated that reactive oxygen species might be involved in FPP-3-induced hepatotoxicity." @default.
- W2146291969 created "2016-06-24" @default.
- W2146291969 creator A5001802872 @default.
- W2146291969 creator A5018365943 @default.
- W2146291969 creator A5022253992 @default.
- W2146291969 creator A5047995856 @default.
- W2146291969 creator A5055083737 @default.
- W2146291969 creator A5059261116 @default.
- W2146291969 creator A5059370020 @default.
- W2146291969 creator A5061055489 @default.
- W2146291969 creator A5064300849 @default.
- W2146291969 creator A5077861192 @default.
- W2146291969 date "2009-07-31" @default.
- W2146291969 modified "2023-09-29" @default.
- W2146291969 title "Hepatotoxic Effects of 1-Furan-2-yl-3-pyridin-2-yl-propenone, a New Anti-Inflammatory Agent, in Mice" @default.
- W2146291969 cites W191793640 @default.
- W2146291969 cites W1966310168 @default.
- W2146291969 cites W1967251260 @default.
- W2146291969 cites W1971817084 @default.
- W2146291969 cites W1975872727 @default.
- W2146291969 cites W1977229794 @default.
- W2146291969 cites W1983310681 @default.
- W2146291969 cites W1991621876 @default.
- W2146291969 cites W1996027317 @default.
- W2146291969 cites W1996143925 @default.
- W2146291969 cites W2007899058 @default.
- W2146291969 cites W2020308594 @default.
- W2146291969 cites W2021775978 @default.
- W2146291969 cites W2024194087 @default.
- W2146291969 cites W2037690748 @default.
- W2146291969 cites W2049690615 @default.
- W2146291969 cites W2069333165 @default.
- W2146291969 cites W2072623135 @default.
- W2146291969 cites W2081596593 @default.
- W2146291969 cites W2088866343 @default.
- W2146291969 cites W2117530523 @default.
- W2146291969 cites W2122857656 @default.
- W2146291969 cites W2161571451 @default.
- W2146291969 cites W2168036511 @default.
- W2146291969 cites W2207356580 @default.
- W2146291969 doi "https://doi.org/10.4062/biomolther.2009.17.3.318" @default.
- W2146291969 hasPublicationYear "2009" @default.
- W2146291969 type Work @default.
- W2146291969 sameAs 2146291969 @default.
- W2146291969 citedByCount "2" @default.
- W2146291969 crossrefType "journal-article" @default.
- W2146291969 hasAuthorship W2146291969A5001802872 @default.
- W2146291969 hasAuthorship W2146291969A5018365943 @default.
- W2146291969 hasAuthorship W2146291969A5022253992 @default.
- W2146291969 hasAuthorship W2146291969A5047995856 @default.
- W2146291969 hasAuthorship W2146291969A5055083737 @default.
- W2146291969 hasAuthorship W2146291969A5059261116 @default.
- W2146291969 hasAuthorship W2146291969A5059370020 @default.
- W2146291969 hasAuthorship W2146291969A5061055489 @default.
- W2146291969 hasAuthorship W2146291969A5064300849 @default.
- W2146291969 hasAuthorship W2146291969A5077861192 @default.
- W2146291969 hasBestOaLocation W21462919691 @default.
- W2146291969 hasConcept C178790620 @default.
- W2146291969 hasConcept C181199279 @default.
- W2146291969 hasConcept C185592680 @default.
- W2146291969 hasConcept C2775838275 @default.
- W2146291969 hasConcept C2777504301 @default.
- W2146291969 hasConcept C2780829032 @default.
- W2146291969 hasConcept C48349386 @default.
- W2146291969 hasConcept C519581460 @default.
- W2146291969 hasConcept C55493867 @default.
- W2146291969 hasConcept C71924100 @default.
- W2146291969 hasConcept C98274493 @default.
- W2146291969 hasConceptScore W2146291969C178790620 @default.
- W2146291969 hasConceptScore W2146291969C181199279 @default.
- W2146291969 hasConceptScore W2146291969C185592680 @default.
- W2146291969 hasConceptScore W2146291969C2775838275 @default.
- W2146291969 hasConceptScore W2146291969C2777504301 @default.
- W2146291969 hasConceptScore W2146291969C2780829032 @default.
- W2146291969 hasConceptScore W2146291969C48349386 @default.
- W2146291969 hasConceptScore W2146291969C519581460 @default.
- W2146291969 hasConceptScore W2146291969C55493867 @default.
- W2146291969 hasConceptScore W2146291969C71924100 @default.
- W2146291969 hasConceptScore W2146291969C98274493 @default.
- W2146291969 hasIssue "3" @default.
- W2146291969 hasLocation W21462919691 @default.
- W2146291969 hasOpenAccess W2146291969 @default.
- W2146291969 hasPrimaryLocation W21462919691 @default.
- W2146291969 hasRelatedWork W1968339085 @default.
- W2146291969 hasRelatedWork W1983805266 @default.
- W2146291969 hasRelatedWork W2010373170 @default.
- W2146291969 hasRelatedWork W2024909592 @default.
- W2146291969 hasRelatedWork W2051549360 @default.
- W2146291969 hasRelatedWork W2053322737 @default.
- W2146291969 hasRelatedWork W2103900156 @default.
- W2146291969 hasRelatedWork W2274983252 @default.
- W2146291969 hasRelatedWork W2372465667 @default.
- W2146291969 hasRelatedWork W2409306400 @default.
- W2146291969 hasVolume "17" @default.
- W2146291969 isParatext "false" @default.
- W2146291969 isRetracted "false" @default.
- W2146291969 magId "2146291969" @default.
- W2146291969 workType "article" @default.