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- W2146292867 endingPage "279" @default.
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- W2146292867 abstract "Leucine, a branched-chain amino acid that must be supplied in the daily diet, plays an important role in controlling protein synthesis and regulating cell metabolism in various cell types. In pancreatic β cells, leucine acutely stimulates insulin secretion by serving as both metabolic fuel and allosteric activator of glutamate dehydrogenase to enhance glutaminolysis. Leucine has also been shown to regulate gene transcription and protein synthesis in pancreatic islet β cells via both mTOR-dependent and -independent pathways at physiological concentrations. Long-term treatment with leucine has been shown to improve insulin secretory dysfunction of human diabetic islets via upregulation of certain key metabolic genes. In vivo, leucine administration improves glycemic control in humans and rodents with type 2 diabetes. This review summarizes and discusses the recent findings regarding the effects of leucine metabolism on pancreatic β-cell function." @default.
- W2146292867 created "2016-06-24" @default.
- W2146292867 creator A5002889060 @default.
- W2146292867 creator A5005296486 @default.
- W2146292867 creator A5010558103 @default.
- W2146292867 creator A5034012227 @default.
- W2146292867 creator A5048917747 @default.
- W2146292867 date "2010-04-28" @default.
- W2146292867 modified "2023-09-30" @default.
- W2146292867 title "Leucine metabolism in regulation of insulin secretion from pancreatic beta cells" @default.
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