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- W2146302353 abstract "The Illumina Infinium HumanMethylation450 BeadChip (450k) is widely used for the evaluation of DNA methylation levels in large-scale datasets, particularly in cancer. The 450k design allows copy number variant (CNV) calling using existing bioinformatics tools. However, in cancer samples, numerous large-scale aberrations cause shifting in the probe intensities and thereby may result in erroneous CNV calling. Therefore, a baseline correction process is needed. We suggest the maximum peak of probe segment density to correct the shift in the intensities in cancer samples.CopyNumber450kCancer is implemented as an R package. The package with examples can be downloaded at http://cran.r-project.orgnour.marzouka@medsci.uu.seSupplementary data are available at Bioinformatics online." @default.
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- W2146302353 date "2015-11-09" @default.
- W2146302353 modified "2023-10-16" @default.
- W2146302353 title "CopyNumber450kCancer: baseline correction for accurate copy number calling from the 450k methylation array" @default.
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- W2146302353 doi "https://doi.org/10.1093/bioinformatics/btv652" @default.
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