Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146306557> ?p ?o ?g. }
- W2146306557 endingPage "2104" @default.
- W2146306557 startingPage "2093" @default.
- W2146306557 abstract "The chondroitin sulfate proteoglycan versican is one of the major extracellular components in the developing and adult brain. Here, we show that isoforms of versican play different roles in neuronal differentiation and neurite outgrowth. Expression of versican V1 isoform in PC12 cells induced complete differentiation, whereas expression of V2 induced an aborted differentiation accompanied by apoptosis. V1 promoted neurite outgrowth of hippocampal neurons, but V2 failed to do so. V1 transfection enhanced expression of epidermal growth factor receptor and integrins, and facilitated sustained extracellular signal-regulated kinase/MAPK phosphorylation. Blockade of the epidermal growth factor receptor, β1 integrin, or Src significantly inhibited neuronal differentiation. Finally, we demonstrated that versican V1 isoform also promoted differentiation of neural stem cells into neurons. Our results have implications for understanding how versican regulates neuronal development, function, and repair." @default.
- W2146306557 created "2016-06-24" @default.
- W2146306557 creator A5028932344 @default.
- W2146306557 creator A5030362343 @default.
- W2146306557 creator A5037082066 @default.
- W2146306557 creator A5037141178 @default.
- W2146306557 creator A5058008919 @default.
- W2146306557 creator A5063034183 @default.
- W2146306557 creator A5063942792 @default.
- W2146306557 creator A5064715130 @default.
- W2146306557 creator A5090358500 @default.
- W2146306557 date "2004-05-01" @default.
- W2146306557 modified "2023-09-27" @default.
- W2146306557 title "Versican V1 Isoform Induces Neuronal Differentiation and Promotes Neurite Outgrowth" @default.
- W2146306557 cites W1515081605 @default.
- W2146306557 cites W1521949639 @default.
- W2146306557 cites W1605448867 @default.
- W2146306557 cites W1644044233 @default.
- W2146306557 cites W1723871640 @default.
- W2146306557 cites W1866366362 @default.
- W2146306557 cites W1913314522 @default.
- W2146306557 cites W1974828804 @default.
- W2146306557 cites W1976689895 @default.
- W2146306557 cites W1977063541 @default.
- W2146306557 cites W1994166157 @default.
- W2146306557 cites W1998122821 @default.
- W2146306557 cites W2000707439 @default.
- W2146306557 cites W2001308076 @default.
- W2146306557 cites W2002167434 @default.
- W2146306557 cites W2010328277 @default.
- W2146306557 cites W2010706444 @default.
- W2146306557 cites W2011951513 @default.
- W2146306557 cites W2012928251 @default.
- W2146306557 cites W2013381560 @default.
- W2146306557 cites W2014957559 @default.
- W2146306557 cites W2023550672 @default.
- W2146306557 cites W2024384954 @default.
- W2146306557 cites W2024667339 @default.
- W2146306557 cites W2024985960 @default.
- W2146306557 cites W2032466814 @default.
- W2146306557 cites W2038220785 @default.
- W2146306557 cites W2042738496 @default.
- W2146306557 cites W2044858838 @default.
- W2146306557 cites W2046713135 @default.
- W2146306557 cites W2062211424 @default.
- W2146306557 cites W2063645267 @default.
- W2146306557 cites W2072164463 @default.
- W2146306557 cites W2077774191 @default.
- W2146306557 cites W2084162464 @default.
- W2146306557 cites W2090911964 @default.
- W2146306557 cites W2091187766 @default.
- W2146306557 cites W2100281377 @default.
- W2146306557 cites W2117523148 @default.
- W2146306557 cites W2118008848 @default.
- W2146306557 cites W2125696459 @default.
- W2146306557 cites W2136469366 @default.
- W2146306557 cites W2137502661 @default.
- W2146306557 cites W2154443361 @default.
- W2146306557 cites W2154713969 @default.
- W2146306557 cites W2166410441 @default.
- W2146306557 cites W2168876033 @default.
- W2146306557 doi "https://doi.org/10.1091/mbc.e03-09-0667" @default.
- W2146306557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/404007" @default.
- W2146306557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14978219" @default.
- W2146306557 hasPublicationYear "2004" @default.
- W2146306557 type Work @default.
- W2146306557 sameAs 2146306557 @default.
- W2146306557 citedByCount "105" @default.
- W2146306557 countsByYear W21463065572012 @default.
- W2146306557 countsByYear W21463065572013 @default.
- W2146306557 countsByYear W21463065572014 @default.
- W2146306557 countsByYear W21463065572015 @default.
- W2146306557 countsByYear W21463065572016 @default.
- W2146306557 countsByYear W21463065572017 @default.
- W2146306557 countsByYear W21463065572018 @default.
- W2146306557 countsByYear W21463065572019 @default.
- W2146306557 countsByYear W21463065572020 @default.
- W2146306557 countsByYear W21463065572021 @default.
- W2146306557 countsByYear W21463065572022 @default.
- W2146306557 countsByYear W21463065572023 @default.
- W2146306557 crossrefType "journal-article" @default.
- W2146306557 hasAuthorship W2146306557A5028932344 @default.
- W2146306557 hasAuthorship W2146306557A5030362343 @default.
- W2146306557 hasAuthorship W2146306557A5037082066 @default.
- W2146306557 hasAuthorship W2146306557A5037141178 @default.
- W2146306557 hasAuthorship W2146306557A5058008919 @default.
- W2146306557 hasAuthorship W2146306557A5063034183 @default.
- W2146306557 hasAuthorship W2146306557A5063942792 @default.
- W2146306557 hasAuthorship W2146306557A5064715130 @default.
- W2146306557 hasAuthorship W2146306557A5090358500 @default.
- W2146306557 hasBestOaLocation W21463065572 @default.
- W2146306557 hasConcept C104317684 @default.
- W2146306557 hasConcept C113246987 @default.
- W2146306557 hasConcept C148738053 @default.
- W2146306557 hasConcept C159470946 @default.
- W2146306557 hasConcept C189165786 @default.
- W2146306557 hasConcept C202751555 @default.
- W2146306557 hasConcept C2775895372 @default.