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- W2146324651 abstract "Vascular endothelial growth factor C (VEGF-C) has been identified as a multifaceted factor participating in the regulation of tumor angiogenesis and lymphangiogenesis. VEGF-C is not only expressed in endothelial cells, but also in tumor cells. VEGF-C signaling is important for progression of various cancer types through both VEGF receptor-2 (VEGFR-2) and VEGF receptor-3 (VEGFR-3). Likewise, both receptors are expressed mainly on endothelial cells, but also expressed in tumor cells. The dimeric VEGF-C undergoes a series of proteolytic cleavage steps that increase the protein binding affinity to VEGFR-3; however, only complete processing, removing both the N- and C-terminal propeptides, yields mature VEGF-C that can bind to VEGFR-2. The processed VEGF-C can bind and activate VEGFR-3 homodimers and VEGFR-2/VEGFR-3 heterodimers to elicit biological responses. High levels of VEGF-C expression and VEGF-C/VEGFRs signaling correlate significantly with poorer prognosis in a variety of malignancies. Therefore, the development of new drugs that selectively target the VEGF-C/VEGFRs axis seems to be an effective means to potentiate anti-tumor therapies in the future." @default.
- W2146324651 created "2016-06-24" @default.
- W2146324651 creator A5030796548 @default.
- W2146324651 creator A5040626069 @default.
- W2146324651 creator A5045417236 @default.
- W2146324651 creator A5052305936 @default.
- W2146324651 creator A5083630845 @default.
- W2146324651 date "2012-12-20" @default.
- W2146324651 modified "2023-10-14" @default.
- W2146324651 title "The Role of the VEGF-C/VEGFRs Axis in Tumor Progression and Therapy" @default.
- W2146324651 cites W1489873347 @default.
- W2146324651 cites W1527031583 @default.
- W2146324651 cites W1527522386 @default.
- W2146324651 cites W1570971207 @default.
- W2146324651 cites W1674445561 @default.
- W2146324651 cites W1825600177 @default.
- W2146324651 cites W1967152628 @default.
- W2146324651 cites W1969695473 @default.
- W2146324651 cites W1970616812 @default.
- W2146324651 cites W1971952583 @default.
- W2146324651 cites W1972070208 @default.
- W2146324651 cites W1972502482 @default.
- W2146324651 cites W1972779338 @default.
- W2146324651 cites W1973662262 @default.
- W2146324651 cites W1974097718 @default.
- W2146324651 cites W1975911973 @default.
- W2146324651 cites W1985060612 @default.
- W2146324651 cites W1985862855 @default.
- W2146324651 cites W1988237607 @default.
- W2146324651 cites W1989940919 @default.
- W2146324651 cites W1991650216 @default.
- W2146324651 cites W1991866477 @default.
- W2146324651 cites W1992170081 @default.
- W2146324651 cites W1995658890 @default.
- W2146324651 cites W1997897024 @default.
- W2146324651 cites W1998521388 @default.
- W2146324651 cites W2001550186 @default.
- W2146324651 cites W2001721526 @default.
- W2146324651 cites W2007560270 @default.
- W2146324651 cites W2008691375 @default.
- W2146324651 cites W2009962397 @default.
- W2146324651 cites W2010897035 @default.
- W2146324651 cites W2010947174 @default.
- W2146324651 cites W2011343016 @default.
- W2146324651 cites W2013692456 @default.
- W2146324651 cites W2013730676 @default.
- W2146324651 cites W2014608793 @default.
- W2146324651 cites W2017174424 @default.
- W2146324651 cites W2017818722 @default.
- W2146324651 cites W2017879489 @default.
- W2146324651 cites W2018729653 @default.
- W2146324651 cites W2023052504 @default.
- W2146324651 cites W2023766700 @default.
- W2146324651 cites W2024893022 @default.
- W2146324651 cites W2025708528 @default.
- W2146324651 cites W2027839362 @default.
- W2146324651 cites W2027869020 @default.
- W2146324651 cites W2027886908 @default.
- W2146324651 cites W2027981903 @default.
- W2146324651 cites W2030537668 @default.
- W2146324651 cites W2031389814 @default.
- W2146324651 cites W2031499319 @default.
- W2146324651 cites W2032063540 @default.
- W2146324651 cites W2037626596 @default.
- W2146324651 cites W2038814594 @default.
- W2146324651 cites W2040089666 @default.
- W2146324651 cites W2042855108 @default.
- W2146324651 cites W2043780565 @default.
- W2146324651 cites W2044689705 @default.
- W2146324651 cites W2048310021 @default.
- W2146324651 cites W2048935448 @default.
- W2146324651 cites W2049827480 @default.
- W2146324651 cites W2049909857 @default.
- W2146324651 cites W2050888224 @default.
- W2146324651 cites W2051255344 @default.
- W2146324651 cites W2052754353 @default.
- W2146324651 cites W2057697484 @default.
- W2146324651 cites W2058034201 @default.
- W2146324651 cites W2059028399 @default.
- W2146324651 cites W2061151994 @default.
- W2146324651 cites W2061257207 @default.
- W2146324651 cites W2062594120 @default.
- W2146324651 cites W2065178830 @default.
- W2146324651 cites W2067851515 @default.
- W2146324651 cites W2071576057 @default.
- W2146324651 cites W2073704598 @default.
- W2146324651 cites W2075652170 @default.
- W2146324651 cites W2080997194 @default.
- W2146324651 cites W2081369202 @default.
- W2146324651 cites W2082764096 @default.
- W2146324651 cites W2083005649 @default.
- W2146324651 cites W2084280165 @default.
- W2146324651 cites W2085277615 @default.
- W2146324651 cites W2085456223 @default.
- W2146324651 cites W2085904846 @default.
- W2146324651 cites W2086802063 @default.
- W2146324651 cites W2086930561 @default.
- W2146324651 cites W2091324278 @default.