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- W2146329289 abstract "Lysine N-ε-acetylation is a post-translational modification that regulates the function of histone and non-histone proteins. In several malignancies, histone acetyltransferase (HAT) activities are disturbed as a consequence of various genetic or epigenetic alterations. In particular, HATs can function as tumor suppressors, helping cells control cellular proliferation and cell cycle, and also as oncogenes, because abnormal acetylation can activate malignant proteins and contribute to cancer. An impaired acetylation profile can be indicative of a pathological process, and thus evaluation of histone acetylation could be used as a predictive index of patient survival or therapy outcome. Therefore, epigenetic therapy might be a very effective strategy to defeat cancer. With the use of histone deacetylase inhibitors and acetylation modulators (e.g. HAT inhibitors, bromodomain inhibitors), we are paving the way for a future epigenetic drug control of human diseases." @default.
- W2146329289 created "2016-06-24" @default.
- W2146329289 creator A5007708383 @default.
- W2146329289 creator A5024044392 @default.
- W2146329289 date "2013-01-15" @default.
- W2146329289 modified "2023-10-05" @default.
- W2146329289 title "Cancers with wrong HATs: the impact of acetylation" @default.
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- W2146329289 doi "https://doi.org/10.1093/bfgp/els065" @default.
- W2146329289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23325510" @default.
- W2146329289 hasPublicationYear "2013" @default.
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