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- W2146331369 abstract "Retreatment of persistent (or “recurrent”) carcinoma of the head and neck by means of after-loading 192Ir techniques may prove quite satisfactory. A total of 64 patients were retreated by these techniques from February, 1974 to October, 1975 at the Los Angeles County—University of Southern California Medical Center and the Southern California Cancer Center. Follow-up periods, averaging only 24 months (18 to 36 months), are too short for statistically significant evaluation of survival, but the “response rate” has been gratifying. Only 11 of our 64 patients (17%) have shown no satisfactory response to re-irradiation by interstitial implant. Thirty-one of the 64 patients (49%) have had local control with “good palliation”. Twenty-two of the 64 (34%) had at least 50% regression of tumour with “fair” palliation. Thus 83% have had satisfactory response to retreatment. A considerable number of these have survived to the date of this report. Whereas 36 of the 64 (56%) are now dead, 28 of the 64 otherwise hopeless patients (44%) were alive with at least local control of neoplastic disease. Nineteen (30%) have developed necrosis in the implant area (we consider this an acceptable complication rate in view of the poor prognosis of the patients involved in this report). Our experience leads us to believe that local tissue tolerance to retreatment by this afterloading 192Ir technique is considerably better than that which would be anticipated for retreatment using external irradiation alone. The degree of palliation obtained appears better than that reported for surgery or for chemotherapy in similar studies." @default.
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- W2146331369 date "1978-10-01" @default.
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- W2146331369 title "Iridium-192 afterloaded implant in the retreatment of head and neck cancers" @default.
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- W2146331369 doi "https://doi.org/10.1259/0007-1285-51-610-814" @default.
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