FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146359845> ?p ?o ?g. }

• W2146359845 endingPage "623" @default.
• W2146359845 startingPage "612" @default.
• W2146359845 abstract "Methionine residues and iron-sulphur (FeS) clusters are primary targets of reactive oxygen species in the proteins of micro-organisms. Here, we show that methionine redox modifications help to preserve essential FeS cluster activities in yeast. Mutants defective for the highly conserved methionine sulphoxide reductases (MSRs; which re-reduce oxidized methionines) are sensitive to many pro-oxidants, but here exhibited an unexpected copper resistance. This phenotype was mimicked by methionine sulphoxide supplementation. Microarray analyses highlighted several Cu and Fe homeostasis genes that were upregulated in the mxrDelta double mutant, which lacks both of the yeast MSRs. Of the upregulated genes, the Cu-binding Fe transporter Fet3p proved to be required for the Cu-resistance phenotype. FET3 is known to be regulated by the Aft1 transcription factor, which responds to low mitochondrial FeS-cluster status. Here, constitutive Aft1p expression in the wild-type reproduced the Cu-resistance phenotype, and FeS-cluster functions were found to be defective in the mxrDelta mutant. Genetic perturbation of FeS activity also mimicked FET3-dependent Cu resistance. 55Fe-labelling studies showed that FeS clusters are turned over more rapidly in the mxrDelta mutant than the wild-type, consistent with elevated oxidative targeting of the clusters in MSR-deficient cells. The potential underlying molecular mechanisms of this targeting are discussed. Moreover, the results indicate an important new role for cellular MSR enzymes in helping to protect the essential function of FeS clusters in aerobic settings." @default.
• W2146359845 created "2016-06-24" @default.
• W2146359845 creator A5006567516 @default.
• W2146359845 creator A5021677625 @default.
• W2146359845 creator A5089512446 @default.
• W2146359845 date "2009-02-01" @default.
• W2146359845 modified "2023-09-23" @default.
• W2146359845 title "Methionine sulphoxide reductases protect iron–sulphur clusters from oxidative inactivation in yeast" @default.
• W2146359845 cites W1483456869 @default.
• W2146359845 cites W1489497639 @default.
• W2146359845 cites W1512217186 @default.
• W2146359845 cites W1555682241 @default.
• W2146359845 cites W1581072312 @default.
• W2146359845 cites W1965668748 @default.
• W2146359845 cites W1966072209 @default.
• W2146359845 cites W1969490516 @default.
• W2146359845 cites W1980422087 @default.
• W2146359845 cites W1980774509 @default.
• W2146359845 cites W1981336649 @default.
• W2146359845 cites W1981368357 @default.
• W2146359845 cites W1985700743 @default.
• W2146359845 cites W1987270094 @default.
• W2146359845 cites W1988151613 @default.
• W2146359845 cites W1991379214 @default.
• W2146359845 cites W1992193197 @default.
• W2146359845 cites W1992758160 @default.
• W2146359845 cites W1995707510 @default.
• W2146359845 cites W1998763047 @default.
• W2146359845 cites W2001055223 @default.
• W2146359845 cites W2001959206 @default.
• W2146359845 cites W2004110947 @default.
• W2146359845 cites W2007718373 @default.
• W2146359845 cites W2008613466 @default.
• W2146359845 cites W2011667964 @default.
• W2146359845 cites W2012164150 @default.
• W2146359845 cites W2016106221 @default.
• W2146359845 cites W2019276195 @default.
• W2146359845 cites W2031720375 @default.
• W2146359845 cites W2035672439 @default.
• W2146359845 cites W2038335468 @default.
• W2146359845 cites W2040233742 @default.
• W2146359845 cites W2042535759 @default.
• W2146359845 cites W2044823713 @default.
• W2146359845 cites W2045727840 @default.
• W2146359845 cites W2046440396 @default.
• W2146359845 cites W2046761749 @default.
• W2146359845 cites W2054481440 @default.
• W2146359845 cites W2058913657 @default.
• W2146359845 cites W2067659770 @default.
• W2146359845 cites W2071027109 @default.
• W2146359845 cites W2071307783 @default.
• W2146359845 cites W2072449192 @default.
• W2146359845 cites W2075400482 @default.
• W2146359845 cites W2077117669 @default.
• W2146359845 cites W2082152349 @default.
• W2146359845 cites W2087467144 @default.
• W2146359845 cites W2088152932 @default.
• W2146359845 cites W2091291195 @default.
• W2146359845 cites W2093173456 @default.
• W2146359845 cites W2114070931 @default.
• W2146359845 cites W2116472408 @default.
• W2146359845 cites W2117556618 @default.
• W2146359845 cites W2127137048 @default.
• W2146359845 cites W2130050137 @default.
• W2146359845 cites W2130081922 @default.
• W2146359845 cites W2131737650 @default.
• W2146359845 cites W2135483397 @default.
• W2146359845 cites W2136321020 @default.
• W2146359845 cites W2136728068 @default.
• W2146359845 cites W2137335580 @default.
• W2146359845 cites W2138447779 @default.
• W2146359845 cites W2138456358 @default.
• W2146359845 cites W2138719091 @default.
• W2146359845 cites W2144070387 @default.
• W2146359845 cites W2154046032 @default.
• W2146359845 cites W2165265474 @default.
• W2146359845 cites W2169805130 @default.
• W2146359845 cites W2218418926 @default.
• W2146359845 cites W2575789697 @default.
• W2146359845 cites W4293247451 @default.
• W2146359845 cites W99326050 @default.
• W2146359845 doi "https://doi.org/10.1099/mic.0.022665-0" @default.
• W2146359845 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2653451" @default.
• W2146359845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19202110" @default.
• W2146359845 hasPublicationYear "2009" @default.
• W2146359845 type Work @default.
• W2146359845 sameAs 2146359845 @default.
• W2146359845 citedByCount "23" @default.
• W2146359845 countsByYear W21463598452012 @default.
• W2146359845 countsByYear W21463598452013 @default.
• W2146359845 countsByYear W21463598452014 @default.
• W2146359845 countsByYear W21463598452016 @default.
• W2146359845 countsByYear W21463598452017 @default.
• W2146359845 countsByYear W21463598452018 @default.
• W2146359845 countsByYear W21463598452019 @default.
• W2146359845 countsByYear W21463598452020 @default.
• W2146359845 countsByYear W21463598452021 @default.
• W2146359845 countsByYear W21463598452022 @default.

• next