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• W2146365313 endingPage "F536" @default.
• W2146365313 startingPage "F517" @default.
• W2146365313 abstract "The mammalian kidney is particularly vulnerable to hypoperfusion, because the O 2 supply to the renal medulla barely exceeds its O 2 requirements. In this study, we examined the impact of the complex structural organization of the rat outer medulla (OM) on O 2 distribution. We extended the region-based mathematical model of the rat OM developed by Layton and Layton ( Am J Physiol Renal Physiol 289: F1346–F1366, 2005) to incorporate the transport of RBCs, Hb, and O 2 . We considered basal cellular O 2 consumption and O 2 consumption for active transport of NaCl across medullary thick ascending limb epithelia. Our model predicts that the structural organization of the OM results in significant Po 2 gradients in the axial and radial directions. The segregation of descending vasa recta, the main supply of O 2 , at the center and immediate periphery of the vascular bundles gives rise to large radial differences in Po 2 between regions, limits O 2 reabsorption from long descending vasa recta, and helps preserve O 2 delivery to the inner medulla. Under baseline conditions, significantly more O 2 is transferred radially between regions by capillary flow, i.e., advection, than by diffusion. In agreement with experimental observations, our results suggest that 79% of the O 2 supplied to the medulla is consumed in the OM and that medullary thick ascending limbs operate on the brink of hypoxia." @default.
• W2146365313 created "2016-06-24" @default.
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• W2146365313 date "2009-08-01" @default.
• W2146365313 modified "2023-10-15" @default.
• W2146365313 title "A mathematical model of O₂transport in the rat outer medulla. I. Model formulation and baseline results" @default.
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• W2146365313 doi "https://doi.org/10.1152/ajprenal.90496.2008" @default.
• W2146365313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2724254" @default.
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