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• W2146366329 abstract "Genetic studies suggest a role for killer cell immunoglobulin-like receptor/HLA (KIR/HLA) compound genotypes in the outcome of viral infections, but functional data to explain these epidemiological observations have not been reported. Using an in vitro model of infection with influenza A virus (IAV), we attribute functional differences in human NK cell activity to distinct KIR/HLA genotypes. Multicolor flow cytometry revealed that the HLA-C–inhibited NK cell subset in HLA-C1 homozygous subjects was larger and responded more rapidly in IFN-γ secretion and CD107a degranulation assays than its counterpart in HLA-C2 homozygous subjects. The differential IFN-γ response was also observed at the level of bulk NK cells and was independent of KIR3DL1/HLA-Bw4 interactions. Moreover, the differential response was not caused by differences in NK cell maturation status and phenotype, nor by differences in the type I IFN response of IAV-infected accessory cells between HLA-C1 and HLA-C2 homozygous subjects. These results provide functional evidence for differential NK cell responsiveness depending on KIR/HLA genotype and may provide useful insights into differential innate immune responsiveness to viral infections such as IAV." @default.
• W2146366329 created "2016-06-24" @default.
• W2146366329 creator A5007653095 @default.
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• W2146366329 creator A5028263779 @default.
• W2146366329 creator A5031039041 @default.
• W2146366329 date "2008-02-01" @default.
• W2146366329 modified "2023-10-13" @default.
• W2146366329 title "Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses" @default.
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• W2146366329 doi "https://doi.org/10.1172/jci32400" @default.
• W2146366329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2214845" @default.
• W2146366329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18246204" @default.
• W2146366329 hasPublicationYear "2008" @default.
• W2146366329 type Work @default.
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