FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146366919> ?p ?o ?g. }

• W2146366919 endingPage "11063" @default.
• W2146366919 startingPage "11051" @default.
• W2146366919 abstract "ABSTRACT Kaposi's sarcoma-associated herpesvirus (also named human herpesvirus 8) is a γ-herpesvirus that undergoes both lytic and latent infection. During latent infection, two viral elements are required: latency-associated nuclear antigen (LANA), which functions as an origin binding protein, and the latent origin, which resides within the terminal repeats (TRs) of the viral genome. Previously, we identified two cis -elements within the TRs which are required for latent DNA replication: two LANA binding sites (LBS1 and LBS2 [LBS1/2]) and a GC-rich replication element (RE) upstream of LBS1/2. To further characterize the RE, we constructed a 71-bp minimal replicon (MR) and performed a detailed mutational analysis. Our data indicate that the first 8 nucleotides within the RE are critical for replication. Moreover, both the position and the distance between the RE and LBS1/2 can affect origin replication activity, suggesting that the RE may function as a loading pad for cellular proteins involved in replication. Using biotinylated DNA fragments of wild-type or mutant MRs as probes, we identified 30 proteins that preferentially bind to the origin. Among these proteins, structure-specific recognition protein 1 (SSRP1), a subunit of the FACT complex, and telomeric repeat binding factor 2 (TRF2) formed complexes with LANA at the MR region. Furthermore, the small interfering RNA-based knockdown of SSRP1, but not the dominant-negative-based knockdown of TRF2, significantly decreased the efficiency of LANA-dependent DNA replication. These results indicate that SSRP1 is a novel cellular protein involved in LANA-dependent DNA replication." @default.
• W2146366919 created "2016-06-24" @default.
• W2146366919 creator A5032322535 @default.
• W2146366919 creator A5047905175 @default.
• W2146366919 creator A5064342343 @default.
• W2146366919 date "2009-11-01" @default.
• W2146366919 modified "2023-09-27" @default.
• W2146366919 title "Involvement of SSRP1 in Latent Replication of Kaposi's Sarcoma-Associated Herpesvirus" @default.
• W2146366919 cites W1491026704 @default.
• W2146366919 cites W1554851690 @default.
• W2146366919 cites W1566845420 @default.
• W2146366919 cites W1593021735 @default.
• W2146366919 cites W1594478849 @default.
• W2146366919 cites W1604210388 @default.
• W2146366919 cites W1673837423 @default.
• W2146366919 cites W1856464455 @default.
• W2146366919 cites W1965641444 @default.
• W2146366919 cites W1974538337 @default.
• W2146366919 cites W1982806023 @default.
• W2146366919 cites W1987997365 @default.
• W2146366919 cites W1988760901 @default.
• W2146366919 cites W1991251689 @default.
• W2146366919 cites W1995782808 @default.
• W2146366919 cites W2004835054 @default.
• W2146366919 cites W2009631763 @default.
• W2146366919 cites W2012929231 @default.
• W2146366919 cites W2013739925 @default.
• W2146366919 cites W2015808098 @default.
• W2146366919 cites W2016775797 @default.
• W2146366919 cites W2018138792 @default.
• W2146366919 cites W2021522625 @default.
• W2146366919 cites W2024474048 @default.
• W2146366919 cites W2028318125 @default.
• W2146366919 cites W2032438721 @default.
• W2146366919 cites W2045327902 @default.
• W2146366919 cites W2046306550 @default.
• W2146366919 cites W2066410692 @default.
• W2146366919 cites W2069792902 @default.
• W2146366919 cites W2075339979 @default.
• W2146366919 cites W2078682316 @default.
• W2146366919 cites W2078738843 @default.
• W2146366919 cites W2078761626 @default.
• W2146366919 cites W2080993511 @default.
• W2146366919 cites W2082281799 @default.
• W2146366919 cites W2104605112 @default.
• W2146366919 cites W2106882164 @default.
• W2146366919 cites W2110188670 @default.
• W2146366919 cites W2119671795 @default.
• W2146366919 cites W2123336494 @default.
• W2146366919 cites W2123422243 @default.
• W2146366919 cites W2132451996 @default.
• W2146366919 cites W2134447274 @default.
• W2146366919 cites W2135375985 @default.
• W2146366919 cites W2142611898 @default.
• W2146366919 cites W2149469688 @default.
• W2146366919 cites W2152736091 @default.
• W2146366919 cites W2155587524 @default.
• W2146366919 cites W2158784184 @default.
• W2146366919 cites W2159462264 @default.
• W2146366919 cites W2170085122 @default.
• W2146366919 cites W2170096097 @default.
• W2146366919 cites W2336241188 @default.
• W2146366919 cites W2410723119 @default.
• W2146366919 cites W4231719396 @default.
• W2146366919 doi "https://doi.org/10.1128/jvi.00907-09" @default.
• W2146366919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2772803" @default.
• W2146366919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19710137" @default.
• W2146366919 hasPublicationYear "2009" @default.
• W2146366919 type Work @default.
• W2146366919 sameAs 2146366919 @default.
• W2146366919 citedByCount "31" @default.
• W2146366919 countsByYear W21463669192012 @default.
• W2146366919 countsByYear W21463669192013 @default.
• W2146366919 countsByYear W21463669192014 @default.
• W2146366919 countsByYear W21463669192015 @default.
• W2146366919 countsByYear W21463669192016 @default.
• W2146366919 countsByYear W21463669192017 @default.
• W2146366919 countsByYear W21463669192018 @default.
• W2146366919 countsByYear W21463669192019 @default.
• W2146366919 countsByYear W21463669192021 @default.
• W2146366919 crossrefType "journal-article" @default.
• W2146366919 hasAuthorship W2146366919A5032322535 @default.
• W2146366919 hasAuthorship W2146366919A5047905175 @default.
• W2146366919 hasAuthorship W2146366919A5064342343 @default.
• W2146366919 hasBestOaLocation W21463669192 @default.
• W2146366919 hasConcept C104690221 @default.
• W2146366919 hasConcept C140704245 @default.
• W2146366919 hasConcept C151158763 @default.
• W2146366919 hasConcept C153911025 @default.
• W2146366919 hasConcept C159047783 @default.
• W2146366919 hasConcept C175193931 @default.
• W2146366919 hasConcept C182615771 @default.
• W2146366919 hasConcept C188036394 @default.
• W2146366919 hasConcept C22840021 @default.
• W2146366919 hasConcept C2522874641 @default.
• W2146366919 hasConcept C2778852064 @default.
• W2146366919 hasConcept C54355233 @default.
• W2146366919 hasConcept C552990157 @default.

• next