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- W2146366988 abstract "Keller MB, McCullough JP, Klein DN, et al. A comparison of nefazodone, the cognitive behavioral-analysis system of psychotherapy, and their combination for the treatment of chronic depression . N Engl J Med2000 May 18; 342 : 1462 –70. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: In patients with chronic forms of major depression, how effective is nefazodone, psychotherapy, and their combination in reducing relapse? Randomised (allocation concealed*), blinded (outcome assessor)*, controlled trial with 12 weeks of follow up. 12 academic centres in the US. 681 patients between 18 and 75 years of age (mean age 43 y, 65% women) with a DSM-IV diagnosis of a chronic major depressive disorder of at least 2 years duration and a score of least 20 on the 24 item Hamilton Rating Scale for Depression (HRSD). Exclusion criteria included a history of seizures, severe head trauma, or stroke; high risk of suicide; history of psychotic symptoms or schizophrenia; bipolar … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.aulast%253DKeller%26rft.auinit1%253DM.%2BB.%26rft.volume%253D342%26rft.issue%253D20%26rft.spage%253D1462%26rft.epage%253D1470%26rft.atitle%253DA%2BComparison%2Bof%2BNefazodone%252C%2Bthe%2BCognitive%2BBehavioral-Analysis%2BSystem%2Bof%2BPsychotherapy%252C%2Band%2BTheir%2BCombination%2Bfor%2Bthe%2BTreatment%2Bof%2BChronic%2BDepression%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJM200005183422001%26rft_id%253Dinfo%253Apmid%252F10816183%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJM200005183422001&link_type=DOI [3]: /lookup/external-ref?access_num=10816183&link_type=MED&atom=%2Febmental%2F3%2F4%2F111.atom [4]: /lookup/external-ref?access_num=000087068200001&link_type=ISI" @default.
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- W2146366988 date "2000-11-01" @default.
- W2146366988 modified "2023-10-16" @default.
- W2146366988 title "The combination of nefazodone and psychotherapy was more effective than either treatment alone in chronic depression" @default.
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