FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146374480> ?p ?o ?g. }

• W2146374480 endingPage "594" @default.
• W2146374480 startingPage "583" @default.
• W2146374480 abstract "Summary The main virulence factor of group A streptococcus (GAS), M protein, binds plasma complement regulators factor H (FH) and FH‐like protein 1 (FHL‐1) leading to decreased opsonization. The M protein binding site on FH is within domain 7 in which also the age‐related macular degeneration (AMD)‐associated polymorphism Y402H is located. We studied if FH allotypes 402H and 402Y have different binding affinities to GAS. Plasma‐derived FH allotype 402H and its recombinant fragment FH5‐7(402H) showed decreased binding to several GAS strains. Growth of GAS in human blood taken from FH(402H) homozygous individuals was decreased when compared with blood taken from FH(402Y) homozygous individuals. The effect of the allotype 402H can be explained by combining the previous M protein mutagenesis data and the recently published crystal structure of FH6‐8. In conclusion the data indicate that the AMD‐associated allotype 402H leads to diminished binding of FH to GAS and increased opsonophagocytosis of the bacteria in blood. These results suggest that the homozygous presence of the allele 402H could be associated with decreased risk for severe GAS infections offering an explanation for the high frequency of the allele despite its association with visual impairment." @default.
• W2146374480 created "2016-06-24" @default.
• W2146374480 creator A5019123072 @default.
• W2146374480 creator A5026241120 @default.
• W2146374480 creator A5029611751 @default.
• W2146374480 creator A5037279359 @default.
• W2146374480 creator A5049420130 @default.
• W2146374480 creator A5085999190 @default.
• W2146374480 date "2008-10-03" @default.
• W2146374480 modified "2023-10-15" @default.
• W2146374480 title "Complement factor H allotype 402H is associated with increased C3b opsonization and phagocytosis of <i>Streptococcus pyogenes</i>" @default.
• W2146374480 cites W111924924 @default.
• W2146374480 cites W1492385697 @default.
• W2146374480 cites W1503240365 @default.
• W2146374480 cites W1512004848 @default.
• W2146374480 cites W1529745308 @default.
• W2146374480 cites W1541085566 @default.
• W2146374480 cites W1564844664 @default.
• W2146374480 cites W1600561684 @default.
• W2146374480 cites W1807239360 @default.
• W2146374480 cites W1895284008 @default.
• W2146374480 cites W1930290089 @default.
• W2146374480 cites W1934585871 @default.
• W2146374480 cites W1965524589 @default.
• W2146374480 cites W1979756776 @default.
• W2146374480 cites W1983191906 @default.
• W2146374480 cites W1985498833 @default.
• W2146374480 cites W1987938286 @default.
• W2146374480 cites W2002537247 @default.
• W2146374480 cites W2005862184 @default.
• W2146374480 cites W2013137776 @default.
• W2146374480 cites W2013188880 @default.
• W2146374480 cites W2018133348 @default.
• W2146374480 cites W2028247608 @default.
• W2146374480 cites W2041966431 @default.
• W2146374480 cites W2044465102 @default.
• W2146374480 cites W2061501964 @default.
• W2146374480 cites W2068933681 @default.
• W2146374480 cites W2074286693 @default.
• W2146374480 cites W2074549590 @default.
• W2146374480 cites W2088140700 @default.
• W2146374480 cites W2113784410 @default.
• W2146374480 cites W2114602085 @default.
• W2146374480 cites W2117386992 @default.
• W2146374480 cites W2121600157 @default.
• W2146374480 cites W2125236492 @default.
• W2146374480 cites W2126297561 @default.
• W2146374480 cites W2128624830 @default.
• W2146374480 cites W2138610380 @default.
• W2146374480 cites W2139377393 @default.
• W2146374480 cites W2140599660 @default.
• W2146374480 cites W2142247182 @default.
• W2146374480 cites W2146052711 @default.
• W2146374480 cites W2148740955 @default.
• W2146374480 cites W2151652430 @default.
• W2146374480 cites W2152235266 @default.
• W2146374480 cites W2154893314 @default.
• W2146374480 cites W2155989698 @default.
• W2146374480 cites W2161469264 @default.
• W2146374480 cites W2166910228 @default.
• W2146374480 cites W2330420020 @default.
• W2146374480 cites W2346909892 @default.
• W2146374480 cites W2409249692 @default.
• W2146374480 cites W3145351529 @default.
• W2146374480 doi "https://doi.org/10.1111/j.1365-2958.2008.06347.x" @default.
• W2146374480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18627465" @default.
• W2146374480 hasPublicationYear "2008" @default.
• W2146374480 type Work @default.
• W2146374480 sameAs 2146374480 @default.
• W2146374480 citedByCount "48" @default.
• W2146374480 countsByYear W21463744802012 @default.
• W2146374480 countsByYear W21463744802013 @default.
• W2146374480 countsByYear W21463744802014 @default.
• W2146374480 countsByYear W21463744802015 @default.
• W2146374480 countsByYear W21463744802016 @default.
• W2146374480 countsByYear W21463744802017 @default.
• W2146374480 countsByYear W21463744802018 @default.
• W2146374480 countsByYear W21463744802019 @default.
• W2146374480 countsByYear W21463744802020 @default.
• W2146374480 countsByYear W21463744802021 @default.
• W2146374480 countsByYear W21463744802022 @default.
• W2146374480 countsByYear W21463744802023 @default.
• W2146374480 crossrefType "journal-article" @default.
• W2146374480 hasAuthorship W2146374480A5019123072 @default.
• W2146374480 hasAuthorship W2146374480A5026241120 @default.
• W2146374480 hasAuthorship W2146374480A5029611751 @default.
• W2146374480 hasAuthorship W2146374480A5037279359 @default.
• W2146374480 hasAuthorship W2146374480A5049420130 @default.
• W2146374480 hasAuthorship W2146374480A5085999190 @default.
• W2146374480 hasConcept C104317684 @default.
• W2146374480 hasConcept C111684460 @default.
• W2146374480 hasConcept C14356644 @default.
• W2146374480 hasConcept C159654299 @default.
• W2146374480 hasConcept C160448771 @default.
• W2146374480 hasConcept C168507396 @default.
• W2146374480 hasConcept C179369057 @default.
• W2146374480 hasConcept C180754005 @default.
• W2146374480 hasConcept C182629451 @default.

• next