FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146376078> ?p ?o ?g. }

• W2146376078 endingPage "3152" @default.
• W2146376078 startingPage "3144" @default.
• W2146376078 abstract "Both IgG and secretory IgA Abs in mucosal secretions have been implicated in blocking the earliest events in HIV-1 transit across epithelial barriers, although the mechanisms by which this occurs remain largely unknown. In this study, we report the production and characterization of a human rIgA(2) mAb that carries the V regions of IgG1 b12, a potent and broadly neutralizing anti-gp120 Ab which has been shown to protect macaques against vaginal simian/HIV challenge. Monomeric, dimeric, polymeric, and secretory IgA(2) derivatives of b12 reacted with gp120 and neutralized CCR5- and CXCR4-tropic strains of HIV-1 in vitro. With respect to the protective effects of these Abs at mucosal surfaces, we demonstrated that IgG1 b12 and IgA(2) b12 inhibited the transfer of cell-free HIV-1 from ME-180 cells, a human cervical epithelial cell line, as well as Caco-2 cells, a human colonic epithelial cell line, to human PBMCs. Inhibition of viral transfer was due to the ability of b12 to block both viral attachment to and uptake by epithelial cells. These data demonstrate that IgG and IgA MAbs directed against a highly conserved epitope on gp120 can interfere with the earliest steps in HIV-1 transmission across mucosal surfaces, and reveal a possible mechanism by which b12 protects the vaginal mucosal against viral challenge in vivo." @default.
• W2146376078 created "2016-06-24" @default.
• W2146376078 creator A5000045873 @default.
• W2146376078 creator A5016666452 @default.
• W2146376078 creator A5027638037 @default.
• W2146376078 creator A5034634166 @default.
• W2146376078 creator A5054993002 @default.
• W2146376078 creator A5058546353 @default.
• W2146376078 creator A5067063383 @default.
• W2146376078 creator A5081145360 @default.
• W2146376078 creator A5082050659 @default.
• W2146376078 date "2007-09-01" @default.
• W2146376078 modified "2023-10-18" @default.
• W2146376078 title "Inhibition of HIV-1 Infectivity and Epithelial Cell Transfer by Human Monoclonal IgG and IgA Antibodies Carrying the b12 V Region" @default.
• W2146376078 cites W1528520360 @default.
• W2146376078 cites W1532429032 @default.
• W2146376078 cites W1548282964 @default.
• W2146376078 cites W1594804329 @default.
• W2146376078 cites W1606557261 @default.
• W2146376078 cites W1750136410 @default.
• W2146376078 cites W1820208462 @default.
• W2146376078 cites W1840633113 @default.
• W2146376078 cites W1841458780 @default.
• W2146376078 cites W1929229765 @default.
• W2146376078 cites W1932265838 @default.
• W2146376078 cites W1943975153 @default.
• W2146376078 cites W1966756198 @default.
• W2146376078 cites W1973109814 @default.
• W2146376078 cites W1974368619 @default.
• W2146376078 cites W1981726169 @default.
• W2146376078 cites W1982645316 @default.
• W2146376078 cites W1982769349 @default.
• W2146376078 cites W1984999783 @default.
• W2146376078 cites W1990372134 @default.
• W2146376078 cites W1993974753 @default.
• W2146376078 cites W1998987175 @default.
• W2146376078 cites W2000213886 @default.
• W2146376078 cites W2001285947 @default.
• W2146376078 cites W2001559562 @default.
• W2146376078 cites W2013948998 @default.
• W2146376078 cites W2019000360 @default.
• W2146376078 cites W2023047470 @default.
• W2146376078 cites W2040576304 @default.
• W2146376078 cites W2059979504 @default.
• W2146376078 cites W2065329551 @default.
• W2146376078 cites W2067695164 @default.
• W2146376078 cites W2069659715 @default.
• W2146376078 cites W2070627443 @default.
• W2146376078 cites W2082118079 @default.
• W2146376078 cites W2082672496 @default.
• W2146376078 cites W2090763940 @default.
• W2146376078 cites W2093987632 @default.
• W2146376078 cites W2096387523 @default.
• W2146376078 cites W2099689198 @default.
• W2146376078 cites W2109467642 @default.
• W2146376078 cites W2112631257 @default.
• W2146376078 cites W2142309583 @default.
• W2146376078 cites W2144023036 @default.
• W2146376078 cites W2146285125 @default.
• W2146376078 cites W2148404862 @default.
• W2146376078 cites W2157210912 @default.
• W2146376078 cites W2164678711 @default.
• W2146376078 cites W2320356847 @default.
• W2146376078 cites W40840948 @default.
• W2146376078 cites W4254743277 @default.
• W2146376078 doi "https://doi.org/10.4049/jimmunol.179.5.3144" @default.
• W2146376078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2881690" @default.
• W2146376078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17709529" @default.
• W2146376078 hasPublicationYear "2007" @default.
• W2146376078 type Work @default.
• W2146376078 sameAs 2146376078 @default.
• W2146376078 citedByCount "44" @default.
• W2146376078 countsByYear W21463760782012 @default.
• W2146376078 countsByYear W21463760782013 @default.
• W2146376078 countsByYear W21463760782014 @default.
• W2146376078 countsByYear W21463760782015 @default.
• W2146376078 countsByYear W21463760782016 @default.
• W2146376078 countsByYear W21463760782017 @default.
• W2146376078 countsByYear W21463760782018 @default.
• W2146376078 countsByYear W21463760782019 @default.
• W2146376078 countsByYear W21463760782020 @default.
• W2146376078 countsByYear W21463760782021 @default.
• W2146376078 countsByYear W21463760782022 @default.
• W2146376078 crossrefType "journal-article" @default.
• W2146376078 hasAuthorship W2146376078A5000045873 @default.
• W2146376078 hasAuthorship W2146376078A5016666452 @default.
• W2146376078 hasAuthorship W2146376078A5027638037 @default.
• W2146376078 hasAuthorship W2146376078A5034634166 @default.
• W2146376078 hasAuthorship W2146376078A5054993002 @default.
• W2146376078 hasAuthorship W2146376078A5058546353 @default.
• W2146376078 hasAuthorship W2146376078A5067063383 @default.
• W2146376078 hasAuthorship W2146376078A5081145360 @default.
• W2146376078 hasAuthorship W2146376078A5082050659 @default.
• W2146376078 hasBestOaLocation W21463760781 @default.
• W2146376078 hasConcept C106358424 @default.
• W2146376078 hasConcept C159047783 @default.
• W2146376078 hasConcept C159654299 @default.
• W2146376078 hasConcept C195616568 @default.

• next