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- W2146376487 abstract "The following is our response to the com-ments of K. Metze and R.L. Adam (1).The proto-oncogene c-erbB-2 is encodedin a tyrosine kinase receptor protein that hasbeen described in different tumors and ani-mals. Since the initial report by Slamon et al.(2), which showed an association betweenamplification of this gene and poor progno-sis in breast cancer, several other studieshave demonstrated overexpression of c-erbB-2 in about 10 to 20% of invasive breastcarcinomas. The demonstration of a highpercentage of c-erbB-2 overexpression inbreast carcinomas suggests that it could rep-resent an early event in breast carcinogen-esis in humans (3-8) and dogs (9-11).In our paper (12), we did not find anycorrelation between survival and c-erbB-2expression or nuclear pleomorphism (P >0.05), which is commented on by Metze andAdam (1). Really, the statistical method(Spearman rank correlation) is not the mostadequate to evaluate the survival in this caseas commented by Metze and Adam. How-ever, the analysis by Kaplan-Meier plots assuggested would not be appropriate becauseof the small number of cases studied in ourreport.Quantitative methods used in the evalua-tion or analysis of immunohistochemical andhistological sections are very much discussedin the literature. Even imaging analysis meth-ods do not seem to be standardized yet (13-17). The Hercept Test is the FDA-approved" @default.
- W2146376487 created "2016-06-24" @default.
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- W2146376487 date "2005-02-01" @default.
- W2146376487 modified "2023-09-26" @default.
- W2146376487 title "Response to the Comments of K. Metze and R.L. Adam on the paper c-erbB-2 expression and nuclear pleomorphism in canine mammary tumors" @default.
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- W2146376487 doi "https://doi.org/10.1590/s0100-879x2005000200002" @default.
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