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- W2146386329 abstract "Ring-opening polymerizations of α-amino acid N-carboxyanhydrides (NCAs) initiated with amines typically form polypeptides with uncontrolled molecular weights and broad molecular weight distributions. However, we found that hexamethyldisilazane (HMDS)-mediated controlled NCA polymerizations gave polypeptides with predictable molecular weights and narrow molecular weight distributions. Using MS, NMR, and FT-IR, we demonstrated that the initiation step involved the cleavage of the N−Si bond of HMDS and the formation of a trimethylsilyl carbamate (TMS-CBM) terminal group. Polypeptide chains were propagated through the migration of TMS of the TMS-CBM end group to the incoming monomer and formed a new TMS-CBM terminal group. This organosilicon reagent mediated NCA polymerization offers a metal-free strategy for the convenient synthesis of homo- or block polypeptides with predictable molecular weights and narrow molecular weight distributions." @default.
- W2146386329 created "2016-06-24" @default.
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- W2146386329 date "2007-10-27" @default.
- W2146386329 modified "2023-10-16" @default.
- W2146386329 title "Hexamethyldisilazane-Mediated Controlled Polymerization of α-Amino Acid <i>N</i>-Carboxyanhydrides" @default.
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- W2146386329 doi "https://doi.org/10.1021/ja074961q" @default.
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