FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146388575> ?p ?o ?g. }

• W2146388575 endingPage "3891" @default.
• W2146388575 startingPage "3886" @default.
• W2146388575 abstract "Reperfusion injury of ischemic tissue represents an acute inflammatory response that can cause significant morbidity and mortality. The mechanism of injury is not fully elucidated, but recent studies indicate an important role for natural antibody and the classical pathway of complement. To test the hypothesis that injury is initiated by specific IgM, we have screened a panel of IgM-producing hybridomas prepared from peritoneal cells enriched in B-1 cells. One clone, CM22, was identified that could restore pathogenic injury in RAG-1(-/-) mice in an intestinal model of ischemia/reperfusion (I/R). In situ activation of the classical pathway of complement was evident by deposition of IgM, complement C4, and C3 in damaged tissue after passive transfer of CM22 IgM. Sequence analysis of CM22 Ig heavy and light chains showed germ-line configurations with high homology to a V(H) sequence from the B-1 repertoire and a V(K) of a known polyreactive natural IgM. These data provide definitive evidence that I/R injury can be initiated by clonally specific natural IgM that activates the classical pathway of complement. This finding opens an avenue for identification of I/R-specific self-antigen(s) and early prevention of injury." @default.
• W2146388575 created "2016-06-24" @default.
• W2146388575 creator A5015792240 @default.
• W2146388575 creator A5016748327 @default.
• W2146388575 creator A5026822066 @default.
• W2146388575 creator A5033746515 @default.
• W2146388575 creator A5040538420 @default.
• W2146388575 creator A5045098528 @default.
• W2146388575 creator A5047151049 @default.
• W2146388575 creator A5062274893 @default.
• W2146388575 creator A5069372387 @default.
• W2146388575 creator A5081180580 @default.
• W2146388575 creator A5088171227 @default.
• W2146388575 date "2004-03-03" @default.
• W2146388575 modified "2023-10-15" @default.
• W2146388575 title "Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury" @default.
• W2146388575 cites W1547029341 @default.
• W2146388575 cites W1644900513 @default.
• W2146388575 cites W1959287443 @default.
• W2146388575 cites W1966203216 @default.
• W2146388575 cites W1971214819 @default.
• W2146388575 cites W1993609762 @default.
• W2146388575 cites W2006536058 @default.
• W2146388575 cites W2028626103 @default.
• W2146388575 cites W2039092540 @default.
• W2146388575 cites W2048611938 @default.
• W2146388575 cites W2053186573 @default.
• W2146388575 cites W2066110904 @default.
• W2146388575 cites W2071177681 @default.
• W2146388575 cites W2074592514 @default.
• W2146388575 cites W2096358976 @default.
• W2146388575 cites W2098471323 @default.
• W2146388575 cites W2106870294 @default.
• W2146388575 cites W2115974508 @default.
• W2146388575 cites W2118111457 @default.
• W2146388575 cites W2139320786 @default.
• W2146388575 cites W2140034286 @default.
• W2146388575 cites W2141869953 @default.
• W2146388575 cites W2145103027 @default.
• W2146388575 cites W2150951327 @default.
• W2146388575 cites W2157137233 @default.
• W2146388575 cites W2168147589 @default.
• W2146388575 cites W2248520797 @default.
• W2146388575 cites W2405226438 @default.
• W2146388575 cites W4244454408 @default.
• W2146388575 cites W58734732 @default.
• W2146388575 doi "https://doi.org/10.1073/pnas.0400347101" @default.
• W2146388575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/374339" @default.
• W2146388575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14999103" @default.
• W2146388575 hasPublicationYear "2004" @default.
• W2146388575 type Work @default.
• W2146388575 sameAs 2146388575 @default.
• W2146388575 citedByCount "212" @default.
• W2146388575 countsByYear W21463885752012 @default.
• W2146388575 countsByYear W21463885752013 @default.
• W2146388575 countsByYear W21463885752014 @default.
• W2146388575 countsByYear W21463885752015 @default.
• W2146388575 countsByYear W21463885752016 @default.
• W2146388575 countsByYear W21463885752017 @default.
• W2146388575 countsByYear W21463885752018 @default.
• W2146388575 countsByYear W21463885752019 @default.
• W2146388575 countsByYear W21463885752020 @default.
• W2146388575 countsByYear W21463885752021 @default.
• W2146388575 countsByYear W21463885752022 @default.
• W2146388575 countsByYear W21463885752023 @default.
• W2146388575 crossrefType "journal-article" @default.
• W2146388575 hasAuthorship W2146388575A5015792240 @default.
• W2146388575 hasAuthorship W2146388575A5016748327 @default.
• W2146388575 hasAuthorship W2146388575A5026822066 @default.
• W2146388575 hasAuthorship W2146388575A5033746515 @default.
• W2146388575 hasAuthorship W2146388575A5040538420 @default.
• W2146388575 hasAuthorship W2146388575A5045098528 @default.
• W2146388575 hasAuthorship W2146388575A5047151049 @default.
• W2146388575 hasAuthorship W2146388575A5062274893 @default.
• W2146388575 hasAuthorship W2146388575A5069372387 @default.
• W2146388575 hasAuthorship W2146388575A5081180580 @default.
• W2146388575 hasAuthorship W2146388575A5088171227 @default.
• W2146388575 hasBestOaLocation W21463885752 @default.
• W2146388575 hasConcept C104317684 @default.
• W2146388575 hasConcept C111684460 @default.
• W2146388575 hasConcept C126322002 @default.
• W2146388575 hasConcept C153911025 @default.
• W2146388575 hasConcept C159654299 @default.
• W2146388575 hasConcept C171279029 @default.
• W2146388575 hasConcept C189446657 @default.
• W2146388575 hasConcept C203014093 @default.
• W2146388575 hasConcept C2776553844 @default.
• W2146388575 hasConcept C2776914184 @default.
• W2146388575 hasConcept C2780114680 @default.
• W2146388575 hasConcept C2780898057 @default.
• W2146388575 hasConcept C541997718 @default.
• W2146388575 hasConcept C54355233 @default.
• W2146388575 hasConcept C71924100 @default.
• W2146388575 hasConcept C81089528 @default.
• W2146388575 hasConcept C86803240 @default.
• W2146388575 hasConceptScore W2146388575C104317684 @default.
• W2146388575 hasConceptScore W2146388575C111684460 @default.
• W2146388575 hasConceptScore W2146388575C126322002 @default.

• next