FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146388719> ?p ?o ?g. }

• W2146388719 abstract "ABSTRACT The invasion-associated type III secretion system (T3SS-1) of Salmonella enterica serotype Typhimurium ( S . Typhimurium) activates the transcription factor NF-κB in tissue culture cells and induces inflammatory responses in animal models through unknown mechanisms. Here we show that bacterial delivery or ectopic expression of SipA, a T3SS-1-translocated protein, led to the activation of the NOD1/NOD2 signaling pathway and consequent RIP2-mediated induction of NF-κB-dependent inflammatory responses. SipA-mediated activation of NOD1/NOD2 signaling was independent of bacterial invasion in vitro but required an intact T3SS-1. In the mouse colitis model, SipA triggered mucosal inflammation in wild-type mice but not in NOD1/NOD2-deficient mice. These findings implicate SipA-driven activation of the NOD1/NOD2 signaling pathway as a mechanism by which the T3SS-1 induces inflammatory responses in vitro and in vivo . IMPORTANCE Salmonella enterica serotype Typhimurium ( S . Typhimurium) deploys a type III secretion system (T3SS-1) to induce intestinal inflammation and benefits from the ensuing host response, which enhances growth of the pathogen in the intestinal lumen. However, the mechanisms by which the T3SS-1 triggers inflammatory responses have not been resolved. Here we show that the T3SS-1 effector protein SipA induces NF-κB activation and intestinal inflammation by activating the NOD1/NOD2 signaling pathway. These data suggest that the T3SS-1 escalates innate responses through a SipA-mediated activation of pattern recognition receptors in the host cell cytosol." @default.
• W2146388719 created "2016-06-24" @default.
• W2146388719 creator A5008096563 @default.
• W2146388719 creator A5023066572 @default.
• W2146388719 creator A5035365524 @default.
• W2146388719 creator A5054787075 @default.
• W2146388719 creator A5055198853 @default.
• W2146388719 creator A5072952237 @default.
• W2146388719 creator A5074464318 @default.
• W2146388719 creator A5079348149 @default.
• W2146388719 date "2011-12-30" @default.
• W2146388719 modified "2023-10-15" @default.
• W2146388719 title "A <i>Salmonella</i> Virulence Factor Activates the NOD1/NOD2 Signaling Pathway" @default.
• W2146388719 cites W1653610611 @default.
• W2146388719 cites W1873170840 @default.
• W2146388719 cites W1957962135 @default.
• W2146388719 cites W1964048031 @default.
• W2146388719 cites W1965971815 @default.
• W2146388719 cites W1969501356 @default.
• W2146388719 cites W1969730825 @default.
• W2146388719 cites W1970527727 @default.
• W2146388719 cites W1981659779 @default.
• W2146388719 cites W1987463569 @default.
• W2146388719 cites W1987961129 @default.
• W2146388719 cites W2000707384 @default.
• W2146388719 cites W2008132225 @default.
• W2146388719 cites W2020385414 @default.
• W2146388719 cites W2030207385 @default.
• W2146388719 cites W2033051264 @default.
• W2146388719 cites W2036254362 @default.
• W2146388719 cites W2040876192 @default.
• W2146388719 cites W2047629389 @default.
• W2146388719 cites W2054941036 @default.
• W2146388719 cites W2060690139 @default.
• W2146388719 cites W2060724895 @default.
• W2146388719 cites W2070597700 @default.
• W2146388719 cites W2089152744 @default.
• W2146388719 cites W2095782520 @default.
• W2146388719 cites W2097248465 @default.
• W2146388719 cites W2108348456 @default.
• W2146388719 cites W2111919009 @default.
• W2146388719 cites W2112552808 @default.
• W2146388719 cites W2114048032 @default.
• W2146388719 cites W2118283102 @default.
• W2146388719 cites W2123675453 @default.
• W2146388719 cites W2124519481 @default.
• W2146388719 cites W2128091547 @default.
• W2146388719 cites W2144050991 @default.
• W2146388719 cites W2155538302 @default.
• W2146388719 cites W2167090556 @default.
• W2146388719 cites W2167591869 @default.
• W2146388719 cites W2168812240 @default.
• W2146388719 cites W2170512706 @default.
• W2146388719 cites W2171865415 @default.
• W2146388719 cites W4238855426 @default.
• W2146388719 doi "https://doi.org/10.1128/mbio.00266-11" @default.
• W2146388719 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3238304" @default.
• W2146388719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22186610" @default.
• W2146388719 hasPublicationYear "2011" @default.
• W2146388719 type Work @default.
• W2146388719 sameAs 2146388719 @default.
• W2146388719 citedByCount "50" @default.
• W2146388719 countsByYear W21463887192012 @default.
• W2146388719 countsByYear W21463887192013 @default.
• W2146388719 countsByYear W21463887192014 @default.
• W2146388719 countsByYear W21463887192015 @default.
• W2146388719 countsByYear W21463887192016 @default.
• W2146388719 countsByYear W21463887192017 @default.
• W2146388719 countsByYear W21463887192018 @default.
• W2146388719 countsByYear W21463887192019 @default.
• W2146388719 countsByYear W21463887192020 @default.
• W2146388719 countsByYear W21463887192021 @default.
• W2146388719 countsByYear W21463887192022 @default.
• W2146388719 countsByYear W21463887192023 @default.
• W2146388719 crossrefType "journal-article" @default.
• W2146388719 hasAuthorship W2146388719A5008096563 @default.
• W2146388719 hasAuthorship W2146388719A5023066572 @default.
• W2146388719 hasAuthorship W2146388719A5035365524 @default.
• W2146388719 hasAuthorship W2146388719A5054787075 @default.
• W2146388719 hasAuthorship W2146388719A5055198853 @default.
• W2146388719 hasAuthorship W2146388719A5072952237 @default.
• W2146388719 hasAuthorship W2146388719A5074464318 @default.
• W2146388719 hasAuthorship W2146388719A5079348149 @default.
• W2146388719 hasBestOaLocation W21463887191 @default.
• W2146388719 hasConcept C104317684 @default.
• W2146388719 hasConcept C130211564 @default.
• W2146388719 hasConcept C136449434 @default.
• W2146388719 hasConcept C164027704 @default.
• W2146388719 hasConcept C203014093 @default.
• W2146388719 hasConcept C2776914184 @default.
• W2146388719 hasConcept C2777291061 @default.
• W2146388719 hasConcept C2779607309 @default.
• W2146388719 hasConcept C2781065037 @default.
• W2146388719 hasConcept C49039625 @default.
• W2146388719 hasConcept C51785407 @default.
• W2146388719 hasConcept C523546767 @default.
• W2146388719 hasConcept C54355233 @default.
• W2146388719 hasConcept C55493867 @default.
• W2146388719 hasConcept C60987743 @default.
• W2146388719 hasConcept C62478195 @default.

• next