Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146390400> ?p ?o ?g. }
- W2146390400 endingPage "8747" @default.
- W2146390400 startingPage "8743" @default.
- W2146390400 abstract "Sensory deprivation caused by peripheral injury can trigger functional cortical reorganization across the initially silenced cortical area. It is proposed that intracortical connectivity enables recovery of function within such a lesion projection zone (LPZ), thus substituting lost subcortical input. Here, we investigated retinal lesion-induced changes in the function of lateral connections in the primary visual cortex of the adult rat. Using voltage-sensitive dye recordings, we visualized in millisecond-time resolution spreading synaptic activity across the LPZ. Shortly after lesion, the majority of neurons within the LPZ were subthresholdly activated by delayed propagation of activity that originated from unaffected cortical regions. With longer recovery time, latencies within the LPZ gradually decreased, and activation reached suprathreshold levels. Targeted electrode recordings confirmed that receptive fields of intra-LPZ neurons were displaced to the retinal lesion border while displaying normal orientation and direction selectivity. These results corroborate the view that cortical horizontal connections have a central role in functional reorganization, as revealed here by progressive facilitation of synaptic activity and the traveling wave of excitation that propagates horizontally into the deprived cortical region." @default.
- W2146390400 created "2016-06-24" @default.
- W2146390400 creator A5006519831 @default.
- W2146390400 creator A5012779825 @default.
- W2146390400 creator A5033199258 @default.
- W2146390400 date "2009-05-26" @default.
- W2146390400 modified "2023-09-27" @default.
- W2146390400 title "Strengthening of lateral activation in adult rat visual cortex after retinal lesions captured with voltage-sensitive dye imaging in vivo" @default.
- W2146390400 cites W1499437640 @default.
- W2146390400 cites W1523908489 @default.
- W2146390400 cites W1708584212 @default.
- W2146390400 cites W1899908082 @default.
- W2146390400 cites W1997104647 @default.
- W2146390400 cites W1999320700 @default.
- W2146390400 cites W2000539955 @default.
- W2146390400 cites W2006750542 @default.
- W2146390400 cites W2008058093 @default.
- W2146390400 cites W2009247375 @default.
- W2146390400 cites W2016879987 @default.
- W2146390400 cites W2022941364 @default.
- W2146390400 cites W2023542362 @default.
- W2146390400 cites W2030727658 @default.
- W2146390400 cites W2040859404 @default.
- W2146390400 cites W2051227638 @default.
- W2146390400 cites W2060629000 @default.
- W2146390400 cites W2062417252 @default.
- W2146390400 cites W2062576690 @default.
- W2146390400 cites W2065632196 @default.
- W2146390400 cites W2067212104 @default.
- W2146390400 cites W2070554810 @default.
- W2146390400 cites W2073339688 @default.
- W2146390400 cites W2078968820 @default.
- W2146390400 cites W2078989143 @default.
- W2146390400 cites W2082188137 @default.
- W2146390400 cites W2087258440 @default.
- W2146390400 cites W2094369536 @default.
- W2146390400 cites W2103090901 @default.
- W2146390400 cites W2103250872 @default.
- W2146390400 cites W2103744641 @default.
- W2146390400 cites W2114104729 @default.
- W2146390400 cites W2120890975 @default.
- W2146390400 cites W2125875155 @default.
- W2146390400 cites W2132889095 @default.
- W2146390400 cites W2142467832 @default.
- W2146390400 cites W2142807566 @default.
- W2146390400 cites W2146273418 @default.
- W2146390400 cites W2158935809 @default.
- W2146390400 cites W2239633514 @default.
- W2146390400 cites W2273649138 @default.
- W2146390400 doi "https://doi.org/10.1073/pnas.0900068106" @default.
- W2146390400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2689012" @default.
- W2146390400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19420221" @default.
- W2146390400 hasPublicationYear "2009" @default.
- W2146390400 type Work @default.
- W2146390400 sameAs 2146390400 @default.
- W2146390400 citedByCount "41" @default.
- W2146390400 countsByYear W21463904002012 @default.
- W2146390400 countsByYear W21463904002013 @default.
- W2146390400 countsByYear W21463904002014 @default.
- W2146390400 countsByYear W21463904002015 @default.
- W2146390400 countsByYear W21463904002016 @default.
- W2146390400 countsByYear W21463904002017 @default.
- W2146390400 countsByYear W21463904002018 @default.
- W2146390400 countsByYear W21463904002019 @default.
- W2146390400 countsByYear W21463904002020 @default.
- W2146390400 countsByYear W21463904002021 @default.
- W2146390400 crossrefType "journal-article" @default.
- W2146390400 hasAuthorship W2146390400A5006519831 @default.
- W2146390400 hasAuthorship W2146390400A5012779825 @default.
- W2146390400 hasAuthorship W2146390400A5033199258 @default.
- W2146390400 hasBestOaLocation W21463904001 @default.
- W2146390400 hasConcept C112592302 @default.
- W2146390400 hasConcept C1337776 @default.
- W2146390400 hasConcept C142724271 @default.
- W2146390400 hasConcept C150903083 @default.
- W2146390400 hasConcept C169760540 @default.
- W2146390400 hasConcept C17077164 @default.
- W2146390400 hasConcept C185263204 @default.
- W2146390400 hasConcept C19071747 @default.
- W2146390400 hasConcept C207001950 @default.
- W2146390400 hasConcept C2777093970 @default.
- W2146390400 hasConcept C2777348757 @default.
- W2146390400 hasConcept C2779083617 @default.
- W2146390400 hasConcept C2779345533 @default.
- W2146390400 hasConcept C2780827179 @default.
- W2146390400 hasConcept C2781156865 @default.
- W2146390400 hasConcept C55493867 @default.
- W2146390400 hasConcept C71924100 @default.
- W2146390400 hasConcept C86803240 @default.
- W2146390400 hasConcept C94487597 @default.
- W2146390400 hasConceptScore W2146390400C112592302 @default.
- W2146390400 hasConceptScore W2146390400C1337776 @default.
- W2146390400 hasConceptScore W2146390400C142724271 @default.
- W2146390400 hasConceptScore W2146390400C150903083 @default.
- W2146390400 hasConceptScore W2146390400C169760540 @default.
- W2146390400 hasConceptScore W2146390400C17077164 @default.
- W2146390400 hasConceptScore W2146390400C185263204 @default.
- W2146390400 hasConceptScore W2146390400C19071747 @default.