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- W2146395557 endingPage "51" @default.
- W2146395557 startingPage "25" @default.
- W2146395557 abstract "Mitochondria import most of their proteins from the cytosol. Dynamic protein complexes in the mitochondrial outer and inner membranes are responsible for the specific recognition and membrane translocation of preproteins. The preprotein translocase of the outer mitochondrial membrane contains several import receptors and a general import pore. The preprotein translocase of the inner membrane consists of a channel interacting with preproteins in transit and an import motor that includes the matrix heat shock protein Hsp70. Acidic patches of import components are thought to guide the import of positively charged signal sequences (acid chain hypothesis). Energy input is derived from the inner membrane potential and ATP. Proteins in the mitochondrial matrix are required for proteolytic processing and folding of imported proteins. The dynamic nature of the membrane translocase permits sorting of preproteins at distinct stages of the import pathway." @default.
- W2146395557 created "2016-06-24" @default.
- W2146395557 creator A5014217628 @default.
- W2146395557 creator A5023094153 @default.
- W2146395557 creator A5060028338 @default.
- W2146395557 date "1997-11-01" @default.
- W2146395557 modified "2023-10-13" @default.
- W2146395557 title "MITOCHONDRIAL PREPROTEIN TRANSLOCASE" @default.
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