FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146408106> ?p ?o ?g. }

• W2146408106 endingPage "1945" @default.
• W2146408106 startingPage "1940" @default.
• W2146408106 abstract "Background Lipid peroxidation and platelet activation are thought to be important contributors to the pathogenesis of atherosclerosis. The relevance of their interaction in vivo, however, is unknown. Methods and Results LDL receptor–deficient (LDLR −/− ) mice on a high-fat diet developed extensive atherosclerosis and had increased urinary levels of 8,12- iso -isoprostane (iP) F 2α -VI and 2,3-dinor-thromboxane (Tx) B 2 , markers of in vivo lipid peroxidation and platelet activation, respectively. Vitamin E supplementation suppressed 8,12- iso -iPF 2α -VI biosynthesis and reduced atherosclerosis (65%) without having a significant effect on lipid levels or TxB 2 biosynthesis. Addition of the platelet inhibitor indomethacin to vitamin E simultaneously suppressed 8,12- iso -iPF 2α -VI and TxB 2 , significantly reduced soluble intercellular adhesion molecule-1 and monocyte chemoattractant protein-1, and remarkably, further reduced atherosclerosis (80%). Conclusions These results indicate that in vivo lipid peroxidation and platelet activation coexist in murine atherosclerosis and that lipid peroxidation does not contribute to platelet activation and reflects the oxidant component of the inflammatory response. Our findings suggest that oxidant stress and platelet activation represent 2 distinct therapeutic targets in atherogenesis. We propose that a combination of antioxidants and platelet inhibitors might be rationally evaluated in the prevention of progression of human atherosclerosis." @default.
• W2146408106 created "2016-06-24" @default.
• W2146408106 creator A5013067151 @default.
• W2146408106 creator A5028764377 @default.
• W2146408106 creator A5028802207 @default.
• W2146408106 creator A5072202763 @default.
• W2146408106 creator A5084143272 @default.
• W2146408106 date "2001-10-16" @default.
• W2146408106 modified "2023-10-18" @default.
• W2146408106 title "Lipid Peroxidation and Platelet Activation in Murine Atherosclerosis" @default.
• W2146408106 cites W1068632 @default.
• W2146408106 cites W1492270522 @default.
• W2146408106 cites W1975419167 @default.
• W2146408106 cites W2000545849 @default.
• W2146408106 cites W2001399393 @default.
• W2146408106 cites W2033539598 @default.
• W2146408106 cites W2044230206 @default.
• W2146408106 cites W2044706016 @default.
• W2146408106 cites W2054652522 @default.
• W2146408106 cites W2055855948 @default.
• W2146408106 cites W2081332101 @default.
• W2146408106 cites W2088404163 @default.
• W2146408106 cites W2093784373 @default.
• W2146408106 cites W2105605377 @default.
• W2146408106 cites W2137368776 @default.
• W2146408106 cites W2140372161 @default.
• W2146408106 cites W2149303684 @default.
• W2146408106 cites W2324841714 @default.
• W2146408106 cites W2331216347 @default.
• W2146408106 doi "https://doi.org/10.1161/hc4101.097114" @default.
• W2146408106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11602498" @default.
• W2146408106 hasPublicationYear "2001" @default.
• W2146408106 type Work @default.
• W2146408106 sameAs 2146408106 @default.
• W2146408106 citedByCount "30" @default.
• W2146408106 countsByYear W21464081062012 @default.
• W2146408106 countsByYear W21464081062013 @default.
• W2146408106 countsByYear W21464081062019 @default.
• W2146408106 crossrefType "journal-article" @default.
• W2146408106 hasAuthorship W2146408106A5013067151 @default.
• W2146408106 hasAuthorship W2146408106A5028764377 @default.
• W2146408106 hasAuthorship W2146408106A5028802207 @default.
• W2146408106 hasAuthorship W2146408106A5072202763 @default.
• W2146408106 hasAuthorship W2146408106A5084143272 @default.
• W2146408106 hasBestOaLocation W21464081061 @default.
• W2146408106 hasConcept C126322002 @default.
• W2146408106 hasConcept C134018914 @default.
• W2146408106 hasConcept C150903083 @default.
• W2146408106 hasConcept C185592680 @default.
• W2146408106 hasConcept C203014093 @default.
• W2146408106 hasConcept C207001950 @default.
• W2146408106 hasConcept C2776151105 @default.
• W2146408106 hasConcept C2776785769 @default.
• W2146408106 hasConcept C2777551382 @default.
• W2146408106 hasConcept C2778004101 @default.
• W2146408106 hasConcept C2780340399 @default.
• W2146408106 hasConcept C2780829032 @default.
• W2146408106 hasConcept C2781024287 @default.
• W2146408106 hasConcept C3018697912 @default.
• W2146408106 hasConcept C55493867 @default.
• W2146408106 hasConcept C71924100 @default.
• W2146408106 hasConcept C86803240 @default.
• W2146408106 hasConcept C89560881 @default.
• W2146408106 hasConcept C98274493 @default.
• W2146408106 hasConceptScore W2146408106C126322002 @default.
• W2146408106 hasConceptScore W2146408106C134018914 @default.
• W2146408106 hasConceptScore W2146408106C150903083 @default.
• W2146408106 hasConceptScore W2146408106C185592680 @default.
• W2146408106 hasConceptScore W2146408106C203014093 @default.
• W2146408106 hasConceptScore W2146408106C207001950 @default.
• W2146408106 hasConceptScore W2146408106C2776151105 @default.
• W2146408106 hasConceptScore W2146408106C2776785769 @default.
• W2146408106 hasConceptScore W2146408106C2777551382 @default.
• W2146408106 hasConceptScore W2146408106C2778004101 @default.
• W2146408106 hasConceptScore W2146408106C2780340399 @default.
• W2146408106 hasConceptScore W2146408106C2780829032 @default.
• W2146408106 hasConceptScore W2146408106C2781024287 @default.
• W2146408106 hasConceptScore W2146408106C3018697912 @default.
• W2146408106 hasConceptScore W2146408106C55493867 @default.
• W2146408106 hasConceptScore W2146408106C71924100 @default.
• W2146408106 hasConceptScore W2146408106C86803240 @default.
• W2146408106 hasConceptScore W2146408106C89560881 @default.
• W2146408106 hasConceptScore W2146408106C98274493 @default.
• W2146408106 hasIssue "16" @default.
• W2146408106 hasLocation W21464081061 @default.
• W2146408106 hasLocation W21464081062 @default.
• W2146408106 hasOpenAccess W2146408106 @default.
• W2146408106 hasPrimaryLocation W21464081061 @default.
• W2146408106 hasRelatedWork W1913178294 @default.
• W2146408106 hasRelatedWork W1986728065 @default.
• W2146408106 hasRelatedWork W2042609244 @default.
• W2146408106 hasRelatedWork W2114256259 @default.
• W2146408106 hasRelatedWork W2132010600 @default.
• W2146408106 hasRelatedWork W2146408106 @default.
• W2146408106 hasRelatedWork W2395981065 @default.
• W2146408106 hasRelatedWork W2418130288 @default.
• W2146408106 hasRelatedWork W2566617483 @default.
• W2146408106 hasRelatedWork W2980115092 @default.

• next