FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146409834> ?p ?o ?g. }

• W2146409834 endingPage "812" @default.
• W2146409834 startingPage "804" @default.
• W2146409834 abstract "The mechanisms of myocyte death during cardiac allograft rejection are incompletely understood. In a previous study using a rat heterotopic cardiac allograft model, we showed that cardiac myocyte apoptosis, inducible nitric oxide synthase (iNOS) mRNA, protein and enzyme activity, and nitrotyrosine increased simultaneously during cardiac allograft rejection. This study was designed to investigate whether apoptosis and expression of iNOS occur in human cardiac allograft rejection.Right ventricular endomyocardial biopsies from 30 cases of allograft rejection (International Society of Heart and Lung Transplantation grade 3A/B) were compared with 12 biopsies with no rejection (International Society of Heart and Lung Transplantation grade 0). Samples were co-labeled for apoptosis and muscle actin. Serial sections were stained for iNOS, nitrotyrosine, and the leukocyte markers CD3, CD4, CD8, and CD68 to identify T-cell subpopulations and macrophages.Biopsies with cardiac allograft rejection showed a 30-fold increase of apoptotic cells when compared with controls. Most apoptotic cardiac myocytes were found in proximity to macrophage (CD68+)-rich inflammatory infiltrates. iNOS immunoreactivity was strongest in macrophages and adjacent myocytes, which also showed high levels of nitrotyrosine, representing damage by peroxynitrite.Apoptosis is a major form of myocyte death during human cardiac allograft rejection. Cardiac myocyte apoptosis is closely associated with expression of iNOS in macrophages and myocytes and with nitration of myocyte proteins by peroxynitrite." @default.
• W2146409834 created "2016-06-24" @default.
• W2146409834 creator A5014520801 @default.
• W2146409834 creator A5030584640 @default.
• W2146409834 creator A5043642364 @default.
• W2146409834 creator A5049378459 @default.
• W2146409834 creator A5064677014 @default.
• W2146409834 creator A5090489759 @default.
• W2146409834 date "1998-03-01" @default.
• W2146409834 modified "2023-10-06" @default.
• W2146409834 title "APOPTOSIS AND INCREASED EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE IN HUMAN ALLOGRAFT REJECTION1" @default.
• W2146409834 cites W142053782 @default.
• W2146409834 cites W1538805645 @default.
• W2146409834 cites W1964045078 @default.
• W2146409834 cites W1973190361 @default.
• W2146409834 cites W1974431388 @default.
• W2146409834 cites W1979230311 @default.
• W2146409834 cites W1990543022 @default.
• W2146409834 cites W1991865867 @default.
• W2146409834 cites W1996180957 @default.
• W2146409834 cites W1998792901 @default.
• W2146409834 cites W2019771054 @default.
• W2146409834 cites W2019984014 @default.
• W2146409834 cites W2026084826 @default.
• W2146409834 cites W2029210607 @default.
• W2146409834 cites W2029675113 @default.
• W2146409834 cites W2033191623 @default.
• W2146409834 cites W2041466047 @default.
• W2146409834 cites W2048765753 @default.
• W2146409834 cites W2050236121 @default.
• W2146409834 cites W2054083392 @default.
• W2146409834 cites W2056761641 @default.
• W2146409834 cites W2058591356 @default.
• W2146409834 cites W2064584294 @default.
• W2146409834 cites W2068225706 @default.
• W2146409834 cites W2069907490 @default.
• W2146409834 cites W2077548365 @default.
• W2146409834 cites W2077641692 @default.
• W2146409834 cites W2078297328 @default.
• W2146409834 cites W2078587014 @default.
• W2146409834 cites W2081145901 @default.
• W2146409834 cites W2088749722 @default.
• W2146409834 cites W2089579900 @default.
• W2146409834 cites W2116690382 @default.
• W2146409834 cites W2120751716 @default.
• W2146409834 cites W2121075882 @default.
• W2146409834 cites W2126636055 @default.
• W2146409834 cites W2132024844 @default.
• W2146409834 cites W2138302361 @default.
• W2146409834 cites W2171526567 @default.
• W2146409834 cites W2173390200 @default.
• W2146409834 cites W2313326603 @default.
• W2146409834 cites W2316918019 @default.
• W2146409834 cites W2341478304 @default.
• W2146409834 doi "https://doi.org/10.1097/00007890-199803270-00007" @default.
• W2146409834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9539092" @default.
• W2146409834 hasPublicationYear "1998" @default.
• W2146409834 type Work @default.
• W2146409834 sameAs 2146409834 @default.
• W2146409834 citedByCount "136" @default.
• W2146409834 countsByYear W21464098342012 @default.
• W2146409834 countsByYear W21464098342013 @default.
• W2146409834 countsByYear W21464098342015 @default.
• W2146409834 countsByYear W21464098342017 @default.
• W2146409834 countsByYear W21464098342019 @default.
• W2146409834 countsByYear W21464098342020 @default.
• W2146409834 crossrefType "journal-article" @default.
• W2146409834 hasAuthorship W2146409834A5014520801 @default.
• W2146409834 hasAuthorship W2146409834A5030584640 @default.
• W2146409834 hasAuthorship W2146409834A5043642364 @default.
• W2146409834 hasAuthorship W2146409834A5049378459 @default.
• W2146409834 hasAuthorship W2146409834A5064677014 @default.
• W2146409834 hasAuthorship W2146409834A5090489759 @default.
• W2146409834 hasBestOaLocation W21464098341 @default.
• W2146409834 hasConcept C126322002 @default.
• W2146409834 hasConcept C134018914 @default.
• W2146409834 hasConcept C142724271 @default.
• W2146409834 hasConcept C181199279 @default.
• W2146409834 hasConcept C190283241 @default.
• W2146409834 hasConcept C203014093 @default.
• W2146409834 hasConcept C204232928 @default.
• W2146409834 hasConcept C207200792 @default.
• W2146409834 hasConcept C2776460901 @default.
• W2146409834 hasConcept C2777622882 @default.
• W2146409834 hasConcept C2778784160 @default.
• W2146409834 hasConcept C2779385521 @default.
• W2146409834 hasConcept C2780795997 @default.
• W2146409834 hasConcept C2911091166 @default.
• W2146409834 hasConcept C3018686881 @default.
• W2146409834 hasConcept C519581460 @default.
• W2146409834 hasConcept C55493867 @default.
• W2146409834 hasConcept C71924100 @default.
• W2146409834 hasConcept C86803240 @default.
• W2146409834 hasConceptScore W2146409834C126322002 @default.
• W2146409834 hasConceptScore W2146409834C134018914 @default.
• W2146409834 hasConceptScore W2146409834C142724271 @default.
• W2146409834 hasConceptScore W2146409834C181199279 @default.
• W2146409834 hasConceptScore W2146409834C190283241 @default.

• next