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- W2146425699 abstract "Abstract As the phenotype of adult dermal stem cells is still elusive, and the hematopoietic stem cell is one of the best-characterized stem cells in the body, we tested dermal cell suspensions, sections, and wholemounts in newborn and adult mice for hematopoietic stem cell marker expression. Phenotypic analysis revealed that a small population of CD45+ cells and a large population of CD45– cells expressed CD34, CD117, and stem cell antigen-1 molecules. When cultivated in selected media supplemented with hematopoietic cytokines, total dermal cells, lineage–, and/or highly enriched phenotypically defined cell subsets produced hematopoietic and nonhematopoietic colonies. When injected into lethally irradiated recipient mice, a small percentage of newborn dermal cells was able to migrate into hematopoietic tissues and the skin and survived through the 11-month monitoring period. Our ability to isolate a candidate autologous stem cell pool will make these cells ideal vehicles for genetic manipulation and gene therapy." @default.
- W2146425699 created "2016-06-24" @default.
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- W2146425699 date "2006-07-24" @default.
- W2146425699 modified "2023-10-16" @default.
- W2146425699 title "Characterization, isolation, and differentiation of murine skin cells expressing hematopoietic stem cell markers" @default.
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- W2146425699 doi "https://doi.org/10.1189/jlb.0106015" @default.
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