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- W2146455000 abstract "Growing evidence indicates that Wingless-type (Wnt) signaling plays an important role in the maturation of the central nervous system. We report here that Wingless-type family member 5A (Wnt-5a) is expressed early in development and stimulates dendrite spine morphogenesis, inducing de novo formation of spines and increasing the size of the preexisting ones in hippocampal neurons. Wnt-5a increased intracellular calcium concentration in dendritic processes and the amplitude of NMDA spontaneous miniature currents. Acute application of Wnt-5a increased the amplitude of field excitatory postsynaptic potentials (fEPSP) in hippocampal slices, an effect that was prevented by calcium-channel blockers. The physiological relevance of our findings is supported by studies showing that Wnt scavengers decreased spine density, miniature excitatory postsynaptic currents, and fEPSP amplitude. We conclude that Wnt-5a stimulates different aspects of synaptic differentiation and plasticity in the mammalian central nervous system." @default.
- W2146455000 created "2016-06-24" @default.
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- W2146455000 date "2010-11-17" @default.
- W2146455000 modified "2023-10-02" @default.
- W2146455000 title "Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses" @default.
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- W2146455000 doi "https://doi.org/10.1073/pnas.1010011107" @default.
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