Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146456427> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2146456427 endingPage "154" @default.
- W2146456427 startingPage "151" @default.
- W2146456427 abstract "Objective: To report a case of acarbose-induced hepatotoxicity and compare other reported cases from the literature. Case Summary: A 57-year-old woman with type 2 diabetes mellitus for about 10 years had been treated with insulin glargine 20 units/day since December 19, 2002. Acarbose 100 mg 3-times-daily add-on therapy for inadequate glycemic control was started on June 5, 2003. Six months later, the woman complained of gastrointestinal discomfort; the acarbose dose was decreased to 50 mg 3 times daily thereafter. Laboratory examination later revealed alanine aminotransferase (ALT) 640 U/L (upper reference value 55). To elucidate the possibilities of adverse reactions caused by concurrent use of nutritional supplements and medication, we discontinued propolis extract, Ginkgo biloba, placeta extract, and estrogen. Although no remarkable symptoms were noted thereafter, the abnormal ALT values persisted, and no definite viral or autoimmune etiologies were identified. Acarbose was discontinued in August 2004; aspartate aminotransferase and ALT values returned to normal in October 2004. Discussion: In addition to ruling out other possible etiologic factors, we assessed the probability of acarbose-induced hepatotoxicity by observing the close time relationship between drug administration and the development of signs and symptoms, as well as the close time relationship between drug withdrawal and the normalization of abnormal liver function test values. An objective causality assessment revealed that an adverse drug reaction was probable as determined by both the Naranjo probability scale and the Roussel Uclaf Causality Assessment Method score. Conclusions: Although acarbose-induced hepatotoxicity appears to be uncommon, diabetic patients receiving long-term acarbose therapy should be closely monitored for this adverse effect." @default.
- W2146456427 created "2016-06-24" @default.
- W2146456427 creator A5007717454 @default.
- W2146456427 creator A5008322218 @default.
- W2146456427 creator A5083282548 @default.
- W2146456427 creator A5064999048 @default.
- W2146456427 date "2006-01-01" @default.
- W2146456427 modified "2023-10-16" @default.
- W2146456427 title "Hepatotoxicity Associated with Acarbose Therapy" @default.
- W2146456427 cites W1966268750 @default.
- W2146456427 cites W1971047268 @default.
- W2146456427 cites W1978791168 @default.
- W2146456427 cites W1997380564 @default.
- W2146456427 cites W2002353683 @default.
- W2146456427 cites W2005208228 @default.
- W2146456427 cites W2015950058 @default.
- W2146456427 cites W2067978628 @default.
- W2146456427 cites W2080803543 @default.
- W2146456427 cites W2083333813 @default.
- W2146456427 cites W2087281809 @default.
- W2146456427 cites W2100076167 @default.
- W2146456427 cites W2108968943 @default.
- W2146456427 cites W2117446864 @default.
- W2146456427 cites W2145542533 @default.
- W2146456427 cites W2148003372 @default.
- W2146456427 doi "https://doi.org/10.1345/aph.1g336" @default.
- W2146456427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16317107" @default.
- W2146456427 hasPublicationYear "2006" @default.
- W2146456427 type Work @default.
- W2146456427 sameAs 2146456427 @default.
- W2146456427 citedByCount "57" @default.
- W2146456427 countsByYear W21464564272012 @default.
- W2146456427 countsByYear W21464564272013 @default.
- W2146456427 countsByYear W21464564272014 @default.
- W2146456427 countsByYear W21464564272016 @default.
- W2146456427 countsByYear W21464564272017 @default.
- W2146456427 countsByYear W21464564272018 @default.
- W2146456427 countsByYear W21464564272019 @default.
- W2146456427 countsByYear W21464564272020 @default.
- W2146456427 countsByYear W21464564272021 @default.
- W2146456427 countsByYear W21464564272022 @default.
- W2146456427 countsByYear W21464564272023 @default.
- W2146456427 crossrefType "journal-article" @default.
- W2146456427 hasAuthorship W2146456427A5007717454 @default.
- W2146456427 hasAuthorship W2146456427A5008322218 @default.
- W2146456427 hasAuthorship W2146456427A5064999048 @default.
- W2146456427 hasAuthorship W2146456427A5083282548 @default.
- W2146456427 hasConcept C126322002 @default.
- W2146456427 hasConcept C134018914 @default.
- W2146456427 hasConcept C197934379 @default.
- W2146456427 hasConcept C2776617576 @default.
- W2146456427 hasConcept C2779306644 @default.
- W2146456427 hasConcept C2780035454 @default.
- W2146456427 hasConcept C2780473172 @default.
- W2146456427 hasConcept C2780542314 @default.
- W2146456427 hasConcept C555293320 @default.
- W2146456427 hasConcept C71924100 @default.
- W2146456427 hasConcept C90924648 @default.
- W2146456427 hasConcept C98274493 @default.
- W2146456427 hasConceptScore W2146456427C126322002 @default.
- W2146456427 hasConceptScore W2146456427C134018914 @default.
- W2146456427 hasConceptScore W2146456427C197934379 @default.
- W2146456427 hasConceptScore W2146456427C2776617576 @default.
- W2146456427 hasConceptScore W2146456427C2779306644 @default.
- W2146456427 hasConceptScore W2146456427C2780035454 @default.
- W2146456427 hasConceptScore W2146456427C2780473172 @default.
- W2146456427 hasConceptScore W2146456427C2780542314 @default.
- W2146456427 hasConceptScore W2146456427C555293320 @default.
- W2146456427 hasConceptScore W2146456427C71924100 @default.
- W2146456427 hasConceptScore W2146456427C90924648 @default.
- W2146456427 hasConceptScore W2146456427C98274493 @default.
- W2146456427 hasIssue "1" @default.
- W2146456427 hasLocation W21464564271 @default.
- W2146456427 hasLocation W21464564272 @default.
- W2146456427 hasOpenAccess W2146456427 @default.
- W2146456427 hasPrimaryLocation W21464564271 @default.
- W2146456427 hasRelatedWork W1589946262 @default.
- W2146456427 hasRelatedWork W2015295066 @default.
- W2146456427 hasRelatedWork W2042182322 @default.
- W2146456427 hasRelatedWork W2066909715 @default.
- W2146456427 hasRelatedWork W2076380935 @default.
- W2146456427 hasRelatedWork W2119697794 @default.
- W2146456427 hasRelatedWork W2510681507 @default.
- W2146456427 hasRelatedWork W3031362645 @default.
- W2146456427 hasRelatedWork W3090938678 @default.
- W2146456427 hasRelatedWork W4248781434 @default.
- W2146456427 hasVolume "40" @default.
- W2146456427 isParatext "false" @default.
- W2146456427 isRetracted "false" @default.
- W2146456427 magId "2146456427" @default.
- W2146456427 workType "article" @default.