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- W2146458427 abstract "Summary. The aim of this study was to compare the kinetics of recovery of B (thymus-independent) and T (thymus-dependent) cells in the peripheral blood and bone marrow of children with acute lymphocytic leukaemia (ALL) after long-term immunosupprcssive therapy. B-cells were identified by the presence of immuno-globulins on their surface and T-cells by spontaneous rosette formation with sheep crythrocytes. In peripheral blood of children who had been in remission for more than 3 yr, the percentage of B-lymphocytes bearing detectable IgM and IgG increased from 2–4 mth after therapy was stopped, while the percentage of T-lymphocytes decreased. In bone marrow the number of B-lymphocytes bearing IgM was higher in the first month after therapy than in the following months. This early increase preceded the rise of IgM- and IgG-lymphocytes in peripheral blood. The proportion of T-lymphocytes in bone marrow was significantly lower than in peripheral blood and did not change throughout the recovery phase. No differences in the rebound of peripheral blood B-cells were demonstrated between three children who had relapsed and those who remained in remission. These data demonstrate that after long-term chemotherapy, bone marrow and peripheral blood lymphocytes bearing B- and T-cell surface markers recover with different kinetics. These results suggest that bone in arrow IgM-lymphocytes may be the precursors of circulating lymphocytes bearing IgM and IgG in man." @default.
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- W2146458427 date "1974-07-01" @default.
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- W2146458427 title "Immunological Rebound after Cessation of Long-term Chemotherapy in Acute Lymphocytic Leukaemia: Changes in Distribution of T and B Cell Populations in Bone Marrow and Peripheral Blood" @default.
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- W2146458427 doi "https://doi.org/10.1111/j.1365-2141.1974.tb06813.x" @default.
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