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• W2146459311 abstract "Streptococcus mutans encounters an array of sugar moieties within the oral cavity due to a varied human diet. One such sugar is β- d -glucose 1-phosphate (βDG1P), which must be converted to glucose 6-phosphate (G6P) before further metabolism to lactic acid. The conversion of βDG1P to G6P is mediated by β-phosphoglucomutase, which has not been previously observed in any oral streptococci, but has been extensively characterized and the gene designated pgmB in Lactococcus lactis . An orthologue was identified in S. mutans , SMU.1747c, and deletion of the gene resulted in the inability of the deletion strain to convert βDG1P to G6P, indicating that SMU.1747c is a β-phosphoglucomutase and should be designated pgmB . In this study, we sought to characterize how deletion of pgmB affected known virulence factors of S. mutans , specifically acid tolerance. The Δ pgmB strain showed a decreased ability to survive acid challenge. Additionally, the strain lacking β-phosphoglucomutase had a diminished glycolytic profile compared with the parental strain. Deletion of pgmB had a negative impact on the virulence of S. mutans in the Galleria mellonella (greater wax worm) animal model. Our results indicate that pgmB plays a role at the juncture of carbohydrate metabolism and virulence." @default.
• W2146459311 created "2016-06-24" @default.
• W2146459311 creator A5031825394 @default.
• W2146459311 creator A5046373482 @default.
• W2146459311 creator A5083274605 @default.
• W2146459311 date "2014-04-01" @default.
• W2146459311 modified "2023-09-26" @default.
• W2146459311 title "β-Phosphoglucomutase contributes to aciduricity in Streptococcus mutans" @default.
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• W2146459311 doi "https://doi.org/10.1099/mic.0.075754-0" @default.
• W2146459311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3973451" @default.
• W2146459311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24509501" @default.
• W2146459311 hasPublicationYear "2014" @default.
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