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- W2146462497 abstract "Itching is a characteristic symptom in various forms of dermatosis, such as atopic dermatitis (AD) and consequently it constitutes a major diagnostic criterion [ [1] Hanifin J.M Rajka G Diagnostic features of atopic dermatitis. Acta Derm. Venereol. Suppl. 1980; 92: 44-47 Google Scholar ]. It is well known that with the itch-scratch cycle, there is a strong desire to scratch and when the skin is scratched, lesions are aggravated and itching ensues [ [2] Wahlgren C.F Itch and atopic dermatitis: an overview. J. Dermatol. 1999; 26: 770-779 Crossref PubMed Scopus (181) Google Scholar ]. Therefore, it is important to reduce itching and scratching to prevent aggravation of skin lesions in pruritic diseases and to upgrade the quality of life of patients. Despite being an important symptom in various skin disease, it had been poorly understood because of the difficulty of its quantitative evaluation. One reason for this might be due to the difficulties in behavioral animal experiments on itching. In 1995, Kuraishi et al. reported pruritogenic stimuli, such as compound 48/80, elicit scratching of the stimulated site by the hind paws in mice and that painful stimuli do not elicit scratching behavior [ [3] Kuraishi Y Nagasawa T Hayashi K Satoh M Scratching behavior induced by pruritogenic but not algesiogenic agents in mice. Eur. J. Pharmacol. 1995; 275: 229-233 Crossref PubMed Scopus (365) Google Scholar ]. These findings suggest that cutaneous itching sensation elicit hind-paw scratching behavior in mice and that the scratching behavior is a possible index to evaluate itching." @default.
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- W2146462497 date "2004-06-01" @default.
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- W2146462497 title "Possible antipruritic effects of K+ channel openers in mice" @default.
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- W2146462497 doi "https://doi.org/10.1016/j.jdermsci.2004.02.010" @default.
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