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- W2146508462 abstract "The present study was undertaken to investigate the effect of saponin extract from the root of Bitter kola (Garcinia kola) on the lipid profile of albino rats tissues (Liver, Kidney and Heart). Twenty albino rats were divided into 4 groups of 5 rats each. They were given rats mash and water ad libitum for 2 weeks to acclimatize them; they were then subjected to different doses of saponin extract from the root of Garcinia kola. Group I (control) received an equivalent volume of water, group II received 100mg/Kg body weight of extract, and group III was given 200mg/Kg body weight, while group IV received 400mg/Kg body weight of saponin extract orally everyday for 21days. The serum, heart, liver and kidney were then analysed for Total cholesterol(TC), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C) and Triglycerides(TG). Administration of 100, 200 and 400 mg/kg doses of saponin extract from the root of Garcinia kola led to a significant reduction (P <05) in total cholesterol, LDL cholesterol and Triglyceride levels in the serum, Liver, kidney and heart when compared with the control and a significant increase (P <05) in HDL cholesterol concentration when compared with control. Hyperlipidemia, being an important risk factor for cardiovascular disease, is a serious public health problem in the world. This result suggests a dose dependent hypolipidemic potential of saponin extract from the root of Garcinia kola and could play a cardio protective role." @default.
- W2146508462 created "2016-06-24" @default.
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- W2146508462 date "2013-01-01" @default.
- W2146508462 modified "2023-10-16" @default.
- W2146508462 title "Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola" @default.
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- W2146508462 doi "https://doi.org/10.11648/j.ab.20130101.11" @default.
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