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- W2146547711 abstract "Psychotic symptoms in Alzheimer disease (AD + P) identify a heritable phenotype associated with a more severe course. We recently found an association of AD + P with depression symptom severity. Reports have shown an association of a serotonin-2A receptor (HTR2A) gene T102C polymorphism with AD + P and with depression during AD. We examined the interaction of this common genetic polymorphism with depression and increased psychosis risk. Subjects with possible or probable AD or mild cognitive impairment (MCI) without psychosis at study entry were genotyped for the HTR2A T102C polymorphism and reassessed every 6 months until psychosis onset. Psychotic and depressive symptoms were rated using the CERAD behavioral rating scale (CBRS). Cox proportional hazard models with time-dependent covariates were used to examine associations with psychosis onset. A total of 324 Caucasian subjects completed at least one follow-up exam. Depressive symptom severity was a strong predictor of psychosis onset. Neither psychosis onset nor depression severity was associated with the HTR2A genotype. Genotype interacted with depression severity to moderate the risk of AD + P onset. This did not result from an interaction of HTR2A genotype with antidepressant use. Psychosis onset in AD is strongly associated with severity of depressive symptoms, an association that may be modified by HTR2A genotype." @default.
- W2146547711 created "2016-06-24" @default.
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- W2146547711 date "2007-01-01" @default.
- W2146547711 modified "2023-10-12" @default.
- W2146547711 title "Prediction of psychosis onset in Alzheimer disease: The role of depression symptom severity and the HTR2A T102C polymorphism" @default.
- W2146547711 cites W125227749 @default.
- W2146547711 cites W125461646 @default.
- W2146547711 cites W1965828393 @default.
- W2146547711 cites W1973796603 @default.
- W2146547711 cites W1974992252 @default.
- W2146547711 cites W1976311429 @default.
- W2146547711 cites W1984096877 @default.
- W2146547711 cites W1991071454 @default.
- W2146547711 cites W1992353173 @default.
- W2146547711 cites W1992579105 @default.
- W2146547711 cites W1993379447 @default.
- W2146547711 cites W1996477729 @default.
- W2146547711 cites W1998323848 @default.
- W2146547711 cites W1999265734 @default.
- W2146547711 cites W2001686560 @default.
- W2146547711 cites W2006833690 @default.
- W2146547711 cites W2014711653 @default.
- W2146547711 cites W2015413496 @default.
- W2146547711 cites W2015985963 @default.
- W2146547711 cites W2017930968 @default.
- W2146547711 cites W2018463453 @default.
- W2146547711 cites W2020237866 @default.
- W2146547711 cites W2020451388 @default.
- W2146547711 cites W2020848554 @default.
- W2146547711 cites W2023506257 @default.
- W2146547711 cites W2025572510 @default.
- W2146547711 cites W2030016379 @default.
- W2146547711 cites W2032375045 @default.
- W2146547711 cites W2033262590 @default.
- W2146547711 cites W2036146366 @default.
- W2146547711 cites W2046506824 @default.
- W2146547711 cites W2046870662 @default.
- W2146547711 cites W2049748524 @default.
- W2146547711 cites W2050074375 @default.
- W2146547711 cites W2059086532 @default.
- W2146547711 cites W2064349791 @default.
- W2146547711 cites W2064883972 @default.
- W2146547711 cites W2066635264 @default.
- W2146547711 cites W2068609871 @default.
- W2146547711 cites W2071515749 @default.
- W2146547711 cites W2074037951 @default.
- W2146547711 cites W2075742644 @default.
- W2146547711 cites W2077067029 @default.
- W2146547711 cites W2080379931 @default.
- W2146547711 cites W2082429191 @default.
- W2146547711 cites W2082656717 @default.
- W2146547711 cites W2085832585 @default.
- W2146547711 cites W2088749345 @default.
- W2146547711 cites W2092001235 @default.
- W2146547711 cites W2093154571 @default.
- W2146547711 cites W2097832990 @default.
- W2146547711 cites W2105550070 @default.
- W2146547711 cites W2106134901 @default.
- W2146547711 cites W2108695299 @default.
- W2146547711 cites W2112252954 @default.
- W2146547711 cites W2114624908 @default.
- W2146547711 cites W2115725384 @default.
- W2146547711 cites W2122813545 @default.
- W2146547711 cites W2122878947 @default.
- W2146547711 cites W2123803408 @default.
- W2146547711 cites W2125591528 @default.
- W2146547711 cites W2127707517 @default.
- W2146547711 cites W2130320269 @default.
- W2146547711 cites W2132185464 @default.
- W2146547711 cites W2134564898 @default.
- W2146547711 cites W2138222426 @default.
- W2146547711 cites W2144373877 @default.
- W2146547711 cites W2147024435 @default.
- W2146547711 cites W2147221474 @default.
- W2146547711 cites W2152914034 @default.
- W2146547711 cites W2156220037 @default.
- W2146547711 cites W2165501402 @default.
- W2146547711 cites W2166643169 @default.
- W2146547711 cites W2171954599 @default.
- W2146547711 cites W2172007938 @default.
- W2146547711 cites W2231758341 @default.
- W2146547711 cites W2304312977 @default.
- W2146547711 cites W2317353498 @default.
- W2146547711 cites W2341581210 @default.
- W2146547711 cites W3023137234 @default.
- W2146547711 cites W4244820590 @default.
- W2146547711 cites W4245871925 @default.
- W2146547711 cites W4251308908 @default.
- W2146547711 doi "https://doi.org/10.1002/ajmg.b.30549" @default.
- W2146547711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2818007" @default.