FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146554642> ?p ?o ?g. }

• W2146554642 endingPage "663" @default.
• W2146554642 startingPage "655" @default.
• W2146554642 abstract "Homologous recombination (HR) is essential for faithful repair of DNA lesions yet must be kept in check, as unrestrained HR may compromise genome integrity and lead to premature aging or cancer. To limit unscheduled HR, cells possess DNA helicases capable of preventing excessive recombination. In this study, we show that the human Fbh1 (hFbh1) helicase accumulates at sites of DNA damage or replication stress in a manner dependent fully on its helicase activity and partially on its conserved F box. hFbh1 interacted with single-stranded DNA (ssDNA), the formation of which was required for hFbh1 recruitment to DNA lesions. Conversely, depletion of endogenous Fbh1 or ectopic expression of helicase-deficient hFbh1 attenuated ssDNA production after replication block. Although elevated levels of hFbh1 impaired Rad51 recruitment to ssDNA and suppressed HR, its small interfering RNA–mediated depletion increased the levels of chromatin-associated Rad51 and caused unscheduled sister chromatid exchange. Thus, by possessing both pro- and anti-recombinogenic potential, hFbh1 may cooperate with other DNA helicases in tightly controlling cellular HR activity." @default.
• W2146554642 created "2016-06-24" @default.
• W2146554642 creator A5007759880 @default.
• W2146554642 creator A5018565717 @default.
• W2146554642 creator A5025781046 @default.
• W2146554642 creator A5035498575 @default.
• W2146554642 creator A5063679562 @default.
• W2146554642 creator A5068545062 @default.
• W2146554642 creator A5084317391 @default.
• W2146554642 creator A5090729430 @default.
• W2146554642 date "2009-09-07" @default.
• W2146554642 modified "2023-10-02" @default.
• W2146554642 title "Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities" @default.
• W2146554642 cites W1970304959 @default.
• W2146554642 cites W1973721031 @default.
• W2146554642 cites W1974755980 @default.
• W2146554642 cites W1976768180 @default.
• W2146554642 cites W1979385111 @default.
• W2146554642 cites W2017619447 @default.
• W2146554642 cites W2017682047 @default.
• W2146554642 cites W2023257987 @default.
• W2146554642 cites W2032640722 @default.
• W2146554642 cites W2035692319 @default.
• W2146554642 cites W2041389422 @default.
• W2146554642 cites W2052547134 @default.
• W2146554642 cites W2069757035 @default.
• W2146554642 cites W2087896638 @default.
• W2146554642 cites W2094020226 @default.
• W2146554642 cites W2095357232 @default.
• W2146554642 cites W2100770435 @default.
• W2146554642 cites W2102321696 @default.
• W2146554642 cites W2117193043 @default.
• W2146554642 cites W2123235480 @default.
• W2146554642 cites W2124308316 @default.
• W2146554642 cites W2124677401 @default.
• W2146554642 cites W2152440925 @default.
• W2146554642 cites W2155001149 @default.
• W2146554642 cites W2169741450 @default.
• W2146554642 cites W2170555058 @default.
• W2146554642 doi "https://doi.org/10.1083/jcb.200812138" @default.
• W2146554642 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2742184" @default.
• W2146554642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19736316" @default.
• W2146554642 hasPublicationYear "2009" @default.
• W2146554642 type Work @default.
• W2146554642 sameAs 2146554642 @default.
• W2146554642 citedByCount "82" @default.
• W2146554642 countsByYear W21465546422012 @default.
• W2146554642 countsByYear W21465546422013 @default.
• W2146554642 countsByYear W21465546422014 @default.
• W2146554642 countsByYear W21465546422015 @default.
• W2146554642 countsByYear W21465546422016 @default.
• W2146554642 countsByYear W21465546422017 @default.
• W2146554642 countsByYear W21465546422018 @default.
• W2146554642 countsByYear W21465546422019 @default.
• W2146554642 countsByYear W21465546422020 @default.
• W2146554642 countsByYear W21465546422021 @default.
• W2146554642 countsByYear W21465546422023 @default.
• W2146554642 crossrefType "journal-article" @default.
• W2146554642 hasAuthorship W2146554642A5007759880 @default.
• W2146554642 hasAuthorship W2146554642A5018565717 @default.
• W2146554642 hasAuthorship W2146554642A5025781046 @default.
• W2146554642 hasAuthorship W2146554642A5035498575 @default.
• W2146554642 hasAuthorship W2146554642A5063679562 @default.
• W2146554642 hasAuthorship W2146554642A5068545062 @default.
• W2146554642 hasAuthorship W2146554642A5084317391 @default.
• W2146554642 hasAuthorship W2146554642A5090729430 @default.
• W2146554642 hasBestOaLocation W21465546421 @default.
• W2146554642 hasConcept C102414288 @default.
• W2146554642 hasConcept C102744134 @default.
• W2146554642 hasConcept C104317684 @default.
• W2146554642 hasConcept C113271649 @default.
• W2146554642 hasConcept C134935766 @default.
• W2146554642 hasConcept C143425029 @default.
• W2146554642 hasConcept C153911025 @default.
• W2146554642 hasConcept C156695909 @default.
• W2146554642 hasConcept C158456008 @default.
• W2146554642 hasConcept C161223559 @default.
• W2146554642 hasConcept C177336024 @default.
• W2146554642 hasConcept C178169997 @default.
• W2146554642 hasConcept C2779012473 @default.
• W2146554642 hasConcept C54355233 @default.
• W2146554642 hasConcept C552990157 @default.
• W2146554642 hasConcept C67705224 @default.
• W2146554642 hasConcept C73573662 @default.
• W2146554642 hasConcept C83640560 @default.
• W2146554642 hasConcept C86339819 @default.
• W2146554642 hasConcept C86803240 @default.
• W2146554642 hasConcept C94966510 @default.
• W2146554642 hasConcept C95444343 @default.
• W2146554642 hasConceptScore W2146554642C102414288 @default.
• W2146554642 hasConceptScore W2146554642C102744134 @default.
• W2146554642 hasConceptScore W2146554642C104317684 @default.
• W2146554642 hasConceptScore W2146554642C113271649 @default.
• W2146554642 hasConceptScore W2146554642C134935766 @default.
• W2146554642 hasConceptScore W2146554642C143425029 @default.
• W2146554642 hasConceptScore W2146554642C153911025 @default.
• W2146554642 hasConceptScore W2146554642C156695909 @default.
• W2146554642 hasConceptScore W2146554642C158456008 @default.

• next